Relationship between chronic inflammation and cardiovascular risk factors in children on maintenance hemodialysis
Relationship between chronic inflammation and cardiovascular risk factors in children on maintenance hemodialysis
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DOI：
10.1016/j.transproceed.2005.07.058
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发表时间：
2005-09-01
影响因子：
0.9
通讯作者：
Saatci, U
中科院分区：
文献类型：
--
作者：
Cengi, N;Baskin, E;Saatci, U
心血管疾病是终末期肾衰竭患儿发病和死亡的最重要原因之一。慢性炎症和营养不良被认为是心血管疾病的危险因素。然而，迄今为止，炎症的生物标志物尚未在儿童中得到很好的研究。本研究旨在探讨血液透析患儿慢性炎症与心血管危险因素的关系。27名接受血液透析的患者（14名女孩，13名男孩）的平均年龄为15.3 ± 2.4岁，20名健康儿童（13名女孩，7名男孩）的平均年龄为14.3 ± 2.7岁。C反应蛋白（CRP）、白蛋白、前白蛋白、转铁蛋白、铁蛋白和纤维蛋白原作为炎症标志物进行测量。血液透析患者血清CRP、铁蛋白、血沉均显著高于对照组（P
Cardiovascular disease is one of the most important causes of morbidity and mortality in children with end-stage renal failure. Chronic inflammation and malnutrition have been suggested to be risk factors for cardiovascular disease. However, to date, biomarkers of inflammation have not been well studied in children. The aim of this study was to investigate the relation between chronic inflammation and cardiovascular risk factors in children on hemodialysis therapy. Twenty-seven patients on hemodialysis (14 girls, 13 boys) of mean age 15.3 +/- 2.4 years and 20 healthy children (13 girls, 7 boys) of mean age 14.3 +/- 2.7 years were included the study. C-reactive protein (CRP), albumin, prealbumin, transferrin, ferritin, and fibrinogen were measured as the markers of inflammation. The levels of CRP, ferritin, and erythrocyte sedimentation rate among hemodialysis patients were significantly higher than those of control subjects (P