Calculation of a new Meeh constant and experimental determination of burn size
Calculation of a new Meeh constant and experimental determination of burn size
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DOI：
10.1016/s0305-4179(96)00064-2
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发表时间：
1996-12-01
期刊：
影响因子：
2.7
通讯作者：
Gilpin, DA
中科院分区：
文献类型：
--
作者：
Gilpin, DA
随着分子生物学研究技术的进步，对表面积测定精度的要求比以前更高。本研究旨在确定最准确的Meeh常数，k，为常用的体重范围内的实验大鼠。一个狭窄的重量范围的重要性是赞赏和平面测量数据，从一系列的青少年山，允许一个新的k值计算。此处提供的数字代表了最广泛使用的体重范围内最常用大鼠品系的最大动物数量。在颈椎脱位后，从16只麻醉的雄性Sprague-Dawley大鼠中取出毛皮。对于每只动物，沿着背侧和腹侧表面上的预定面积，通过平面测量法测定总体表面积（TBSA）。将平面测量数据沿着与动物体重一起输入Meeh公式，获得每只大鼠的k值。然后使用平均k（9.46）计算每只动物的表面积，并与使用Meeh常数的历史值获得的数字进行比较。使用新的k值的方法描述了准确测定总体表面积和预定的表面积，在特定重量范围内的实验大鼠。版权所有（C）1996 Elsevier Science Ltd for ISBI。
With advances in research techniques involving molecular biology, the need for precision in the determination of surface area is even greater than previously. This study sets out to determine the most accurate Meeh constant, k, for a commonly used weight range of experimental rats. The importance of a narrow weight range is appreciated and planometric data is presented from a series of adolescent mts that allow a new k value to be calculated. The figures presented here represent the largest number of animals, of a commonly used rat strain, in the most widely used weight range yet described. Pelts were removed from 16 anaesthetized male Sprague-Dawley rats after cervical dislocation. For each animal total body surface area (TBSA) was determined planometrically, along with premarked areas on the dorsal and ventral surfaces. Entering the planometrically measured data along with the animal's weight into the Meeh formula, a k value was obtained for each rat. Surface areas were then calculated for each animal using the mean k, 9.46, and compared against figures obtained by using historical values for the Meeh constant. Using the new k value a method is described for the accurate determination of total body surface area and premarked surface areas, in experimental rats of a specific weight range. Copyright (C) 1996 Elsevier Science Ltd for ISBI.