Stress distribution in a circular membrane with a central fixation
Stress distribution in a circular membrane with a central fixation
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DOI：
10.1115/1.1894389
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发表时间：
2005-06-01
影响因子：
1.7
通讯作者：
Moore, JE
中科院分区：
文献类型：
--
作者：
Mori, D;David, G;Moore, JE
临床干预可以改变靶向治疗组织的机械环境。为了设计更好的程序，了解细胞对机械应力变化的反应是很重要的。刚性固定是由于植入装置而对活组织施加约束的一个例子。这导致了扰动的应力场和应变场，具有潜在的强梯度。在本文中，我们通过在圆周上施加零位移条件，数值求解了有限变形各向异性圆膜内应力分布的非线性常微分方程组。结果表明，刚性固定产生的应力和应变分布与具有无牵引力边界的组织缺损明显不同。此外，无论内固定的大小如何，材料的各向异性在应力重新分布的方式中起着重要的作用。本研究将有助于设计实验，以确定介入治疗失败所涉及的细胞反应。
Clinical interventions can change the mechanical environment of the tissues targeted for therapy. In order to design better procedures, it is important to understand cellular responses to altered mechanical stress. Rigid fixation is one example of a constraint imposed on living tissues as a result of implanted devices. This results in disturbed stress and strain fields, with potentially strong gradients. Herein, we numerically solve the governing nonlinear ordinary differential equation for the stress distribution in a finitely deformed anisotropic circular membrane with a concentric fixation by applying a zero-displacement condition at the inner circumference. Results show that rigid fixations yield distributions of stress and strain that are markedly different from tissue defects with traction-free boundaries. Moreover the material anisotropy plays a significant role in the manner the stress redistributes regardless of the size of fixation. The present study will contribute to the design of experiments to determine cellular reactions involved in the failure of interventional treatments.