Targeting PERK to treat arrhythmias.
Targeting PERK to treat arrhythmias.
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以 PERK 为目标治疗心律失常。
DOI：
10.1016/j.molmed.2023.05.005
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发表时间：
2023
影响因子：
13.6
通讯作者：
DudleyJr,SamuelC
中科院分区：
文献类型：
--
作者：
Liu,Man;Kang,Gyeoung-Jin;DudleyJr,SamuelC
目前的心律失常治疗有很大的局限性。抗抑郁药有副作用。导管消融的效果有限，而且很难知道植入的心脏起搏器对谁最有帮助。最近，我们提出，防止心肌病中发生的离子通道下调可能是一种新的方法，可以降低心肌病风险，而不会产生心肌病后果[
Current treatments for arrhythmia have substantial limitations. Antiarrhythmic drugs have proarrhythmic side effects. Catheter ablation has limited effectiveness, and it is difficult to know in whom implanted cardio-defibrillators would be most helpful. Recently, we proposed that preventing the downregulation of ion channels that occurs in cardiomyopathy may be a novel method to reduce arrhythmic risk without proarrhythmic consequences [