Sesterterpenoids and an alkaloid from a Thorectandra sp as inhibitors of the phosphatase Cdc25B
Sesterterpenoids and an alkaloid from a Thorectandra sp as inhibitors of the phosphatase Cdc25B
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DOI：
10.1016/j.bmc.2005.04.070
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发表时间：
2005-09-01
影响因子：
3.5
通讯作者：
Kingston, DGI
中科院分区：
文献类型：
--
作者：
Cao, SG;Foster, C;Kingston, DGI
通过对一种刺蕊海绵提取物的生物测定定向分离，分离出三种新的二萜类化合物，1,6-氧代丝瓜络内酯（1）、1，6-羟基丝瓜络内酯（2）和（2 E，6 E10 E）-3-甲酰基-7，11-二甲基-13-（2，6，6-trimethylcyclohex-1-enyl）trideca-2，6，10-trienoic acid（3）;两种已知的二萜类化合物，丝瓜络（luffariellidene）（4）和脱氢丝瓜络二酸（dehydroluffariellidene diacid）（5）;和一种已知的生物碱fascaplysin（6）。新化合物1-3的结构是在广泛的ID和2D NMR光谱数据解释的基础上建立的。化合物6在Cdc 25 B测定中显示出抑制活性，IC 50值为1.0 μ g/mL。(c)2005爱思唯尔有限公司保留所有权利。
Bioassay-directed separation of an extract of a Thorectandra sp. sponge led to the isolation of three new sesterterpenoids, 16-oxoluffariellolide (1), 1,6-hydroxyluffariellolide (2), and (2E,6E10E)-3-formyl-7,11-dimethyl-13-(2,6,6-trimethylcyclohex-1-enyl)trideca-2,6,10-trienoic acid (3); two known sesterterpenoids, luffariellolide (4) and dehydroluffariellolide diacid (5); and one known alkaloid, fascaplysin (6). The structures of the new compounds 1-3 were established on the basis of extensive ID and 2D NMR spectroscopic data interpretation. Compound 6 showed inhibitory activity in the Cdc25B assay, with an IC50 value of 1.0 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.