NONINVASIVE QUANTIFICATION OF REGIONAL MYOCARDIAL PERFUSION WITH RB-82 AND POSITRON EMISSION TOMOGRAPHY - EXPLORATION OF A MATHEMATICAL-MODEL
NONINVASIVE QUANTIFICATION OF REGIONAL MYOCARDIAL PERFUSION WITH RB-82 AND POSITRON EMISSION TOMOGRAPHY - EXPLORATION OF A MATHEMATICAL-MODEL
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DOI：
10.1161/01.cir.82.4.1377
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发表时间：
1990-10-01
期刊：
影响因子：
37.8
通讯作者：
BERGMANN, SR
中科院分区：
文献类型：
--
作者：
HERRERO, P;MARKHAM, J;BERGMANN, SR
没有回旋加速器的正电子发射断层扫描（PET）中心使用发生器产生的铷-82（82 Rb）评估心肌灌注。本研究的目的是确定是否可以用82 Rb和PET定量评估心肌血流量。由于心肌~（82）Rb提取分数与流量成反比且非线性变化，不能方便地用PET测量，我们用实验推导出的~（82）Rb单程提取分数与流量关系的数学函数来说明直接测量心肌~（82）Rb提取分数的必要性。心肌血流量的绝对值（ml/g/min）估计从动态PET扫描后，静脉注射82 Rb在完整的狗，并与放射性标记的微球测量流量进行比较。在与13只狗进行的36项比较中，这些狗在静息状态下，或在冠状动脉闭塞后，再灌注后，或在静脉注射潘生丁诱导的冠状动脉充血后，在0.2至2.0 ml/g/min的流量范围内，用铷进行的灌注估计与伴随微球测量的流量相关性良好，虽然用铷的流量稍微低估了（82 Rb的流量= 0.92 × 10 - 4）。微球流动性-0.21，r = 0.83）。一般来说，缺血区域的血流估计值比正常血流区域的估计值可靠性低。因此，虽然心肌提取和保留的82 Rb和流量之间的关系可以在各种生理和病理生理条件下变化，本研究表明，在仔细定义的条件下，无需直接测量提取分数的82 Rb和PET获得心肌血流量的定量估计的能力。
Positron emission tomography (PET) centers without cyclotrons use generator-produced rubidium-82 (82Rb) for assessment of myocardial perfusion. The aim of present study was to determine whether myocardial blood flow could be assessed quantitatively with 82Rb and PET. Because the myocardial extraction fraction 82Rb varies inversely and nonlinearly with flow and cannot be measured conveniently with PET, we used and experimentally derived mathematical function defining the relation between single-pass extraction fraction of 82Rb and flow to obviate the necessity of measuring the extraction fraction directly. Myocardial blood flow in absolute terms (ml/g/min) was estimated from dynamic PET scans after intravenous administration of 82Rb in intact dogs and compared with flows measured with radiolabeled microspheres. In 36 comparisons with 13 dogs studied at rest, or after coronary occlusion, reperfusion, or after coronary hyperemia induced with intravenous dipyridamole, over the flow range from 0.2 to 2.0 ml/g/min, estimates of perfusion with rubidium correlated well with flows measured concomitantly with microspheres, although there was a slight underestimation of flow with rubidium (flow by 82Rb = 0.92 .times. flow by microspheres-0.21, r = 0.83). In general, estimates of flow in ischemic regions were less reliable than estimates for regions with normal flow. Thus, although the relation between myocardial extraction and retention of 82Rb and flow can vary under a variety of physiological and pathophysiological conditions, this study demonstrates the ability to obtain quantitative estimates of myocardial blood flow with 82Rb and PET under carefully defined conditions without measuring the extraction fraction directly.