The Placenta as a Compensatory Iodine Storage Organ
The Placenta as a Compensatory Iodine Storage Organ
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DOI：
10.1089/thy.2010.0203
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发表时间：
2011-05-01
期刊：
影响因子：
6.6
通讯作者：
Smyth, Peter P. A.
中科院分区：
文献类型：
--
作者：
Burns, Robert;O'Herlihy, Colm;Smyth, Peter P. A.
背景资料：胎儿大脑发育所必需的含碘甲状腺激素的产生不仅取决于母体的饮食摄入，还取决于胎盘的碘转运。怀孕期间碘营养的最佳水平和达到这一水平的怀孕人口比例以前已经过评估。关于胎盘积累或储存碘的能力的信息很少。本研究的目的是调查碘吸收和组织碘含量内胎盘组织中获得的妇女在足月分娩。方法：样本（类似于1厘米（3））从胎盘子叶（n = 19），甲状腺（n = 4），子宫肌层（n = 4）组织中获得的培养6小时（125）I在高氯酸钾的存在和不存在。结果：胎盘对（125）I的摄取（375 cpm/μ g DNA）显著高于对照子宫肌层组织（226 cpm/μ g DNA）（P
Background: The production of iodine-containing thyroid hormones necessary for brain development in the fetus depends not only on maternal dietary intake but also on placental iodine transport. The optimum level of iodine nutrition during pregnancy and the proportion of the pregnant population reaching this level have previously been evaluated. Little information exists on the ability of the placenta to either accumulate or store iodine. This study aims to investigate iodine uptake and tissue iodine content within placental tissue obtained from women delivering at term.Methods: Samples (similar to 1 cm(3)) obtained from placental cotyledons (n = 19), thyroid (n = 4), and uterine myometrial (n = 4) tissue were incubated for 6 hours with (125)I in the presence and absence of potassium perchlorate. To account for variation in tissue composition, results were expressed in cpm (125)I/mu g DNA.Results: Placental uptake of (125)I (375 cpm/mu g DNA) was significantly higher than that of control myometrial tissue (226 cpm/mu g DNA) (p