Circadian rhythm in experimental granulomatous inflammation is modulated by melatonin
Circadian rhythm in experimental granulomatous inflammation is modulated by melatonin
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DOI：
10.1111/j.1600-079x.1997.tb00338.x
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发表时间：
1997-09-01
影响因子：
10.3
通讯作者：
Mariano, M
中科院分区：
文献类型：
--
作者：
Lopes, C;DeLyra, JL;Mariano, M
生物节律在人类和动物的各种生理和病理条件下被检测到，如类风湿关节炎和哮喘。本研究描述了实验性感染性和非感染性肉芽肿的昼夜节律，C57B1/6小鼠左后脚接种卡介苗或制霉菌素30天后，脚掌厚度的变化出现一个周期约为24小时的振荡，表明存在昼夜节律。高峰发生在光相，在9:00 ~ 13:00 hr之间，最低点发生在暗相，在21:00 ~ 01:00 hr之间。肉芽肿病灶周围血管通透性在12:00时高于24:00时。这与观察结果一致，肉芽肿病变的爪子在光照期的厚度更大，这种节律变化可以通过松果体切除术或颈上神经节切除术消除，这大大降低了血液中的褪黑激素水平。夜间替代褪黑素在松果体切除小鼠导致昼夜节律的重建。因此，肉芽肿病变的节律是由于松果体有节奏地释放褪黑激素。这种方法打开了新的问题，关于慢性炎症在炎症性疾病的调节，目前全天节律性症状。
Biological rhythms are detected in a variety of physiological and pathological conditions in man and animals, such as rheumatoid arthritis and asthma. Here we describe a circadian rhythm in experimental infectious and non-infectious granuloma, After 30 days of BCG (Bacillus Calmette-Guerin) or nystatin inoculation in the left hind foot of C57B1/6 mice, there is an oscillation with a period of approximately 24 hr in the variation of paw thickness, indicating a circadian rhythm. The acrophase occurred during the light phase, between 9:00 and 13:00 hr, while the nadir occurred in the dark phase, between 21:00 and 01:00 hr. The vascular permeability around the granulomatous lesions was higher at 12:00 hr than at 24:00 hr. This is in agreement with the observation that the thickness of a paw with granulomatous lesion is larger during the light phase,This rhythmic variation was eliminated by either pinealectomy or superior cervical ganglionectomy, which greatly reduce melatonin levels in the blood. Nocturnal replacement of melatonin in pinealectomized mice led to the re-establishment of the circadian rhythm. Thus, the rhythm of the granulomatous lesion is due to the rhythmic melatonin release by the pineal gland. This approach opens new questions regarding the modulation of chronic inflammation in inflammatory diseases that present rhythmic symptoms throughout the day.