Asymmetric conjugate addition of copper reagents to α,β-unsaturated tert-butanesulfinyl imines
Asymmetric conjugate addition of copper reagents to α,β-unsaturated tert-butanesulfinyl imines
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DOI：
10.1021/ol051986q
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发表时间：
2005-11-24
期刊：
影响因子：
5.2
通讯作者：
Ellman, JA
中科院分区：
文献类型：
--
作者：
McMahon, JP;Ellman, JA
将有机铜酸酯加成到N-亚磺酰基α-β-不饱和亚胺中，以良好的产率和良好的非对映选择性进行。α，β-不饱和亚磺酰基酮亚胺和醛亚胺都已被证明是该反应的合适底物。
Addition of organocuprates to N-sulfinyl alpha-beta-unsaturated imines proceeds in good yields and with good diastereoselectivities. alpha,beta-Unsaturated sulfinyl ketimines and aldimines have both been shown to be suitable substrates for this reaction.