Dynamics of HIV infection in lymphoid tissue network
Dynamics of HIV infection in lymphoid tissue network
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DOI：
10.1007/s00285-015-0940-x
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发表时间：
2016-03
影响因子：
1.9
通讯作者：
S. Nakaoka;S. Iwami;Kei Sato
中科院分区：
文献类型：
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作者：
S. Nakaoka;S. Iwami;Kei Sato
人类免疫缺陷病毒（HIV）是一种快速复制的核糖核酸病毒，它可以很容易地变异，以逃避药物管理的影响。因此，了解HIV在体内持续存在的基本机制对于开发能够根除HIV感染的新疗法至关重要。类扁桃体组织是HIV感染的主要部位。尽管最近在实时监测技术方面取得了进展，但整个身体中的艾滋病毒感染动态仍是未知的。数学建模和模拟提供了对淋巴系统中HIV感染的全球行为的推测。我们提出了一个新的数学模型，描述了整个淋巴组织网络的艾滋病毒感染的传播。为了表示淋巴组织之间的体积差异，我们提出了几个动力学参数的淋巴组织的体积分布的比例。在此假设下，我们进行了大量的数值计算，以模拟艾滋病毒感染的淋巴组织网络中的传播。数值计算模拟HIV感染的单一药物治疗。从这项研究中得出的重要生物学推测之一是淋巴网络连接产生的药物饱和效应。这意味着，尽管大量注射药物，但药物未充分递送至的一部分储库淋巴组织将抑制HIV根除。
Human immunodeficiency virus (HIV) is a fast replicating ribonucleic acid virus, which can easily mutate in order to escape the effects of drug administration. Hence, understanding the basic mechanisms underlying HIV persistence in the body is essential in the development of new therapies that could eradicate HIV infection. Lymphoid tissues are the primary sites of HIV infection. Despite the recent progress in real-time monitoring technology, HIV infection dynamics in a whole body is unknown. Mathematical modeling and simulations provide speculations on global behavior of HIV infection in the lymphatic system. We propose a new mathematical model that describes the spread of HIV infection throughout the lymphoid tissue network. In order to represent the volume difference between lymphoid tissues, we propose the proportionality of several kinetic parameters to the lymphoid tissues’ volume distribution. Under this assumption, we perform extensive numerical computations in order to simulate the spread of HIV infection in the lymphoid tissue network. Numerical computations simulate single drug treatments of an HIV infection. One of the important biological speculations derived from this study is a drug saturation effect generated by lymphoid network connection. This implies that a portion of reservoir lymphoid tissues to which drug is not sufficiently delivered would inhibit HIV eradication despite of extensive drug injection.