Diagnostic performance of low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT using the 530c CZT camera: Quantitative vs visual analysis
Diagnostic performance of low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT using the 530c CZT camera: Quantitative vs visual analysis
复制标题
DOI：
10.1007/s12350-013-9827-7
复制
发表时间：
2014-02-01
影响因子：
2.4
通讯作者：
Garcia, Ernest V.
中科院分区：
文献类型：
--
作者：
Esteves, Fabio P.;Galt, James R.;Garcia, Ernest V.
我们开始建立正常数据库，并使用530c CZT摄像机前瞻性地验证小剂量~(99)m四氧嘧啶心肌灌注SPECT的异常标准。所有患者接受6 mCI静息/20 mCI负荷剂量的~(99)m四氢呋喃。根据胸部大小，分别在7-9分钟和5-7分钟内获得休息和负荷图像。胸部低剂量CT扫描在独立的CT扫描仪上进行。用40例极低似然(LLK)冠心病(CAD)患者确定正态计数分布。对55例冠状动脉造影者和40例冠心病LLK患者进行前瞻性验证。定量非衰减校正(AC)、AC分析和视觉分析的结果分别为：敏感性79%、85%和92%(P=NS)，特异性44%、75%和56%(P=NS)。非AC和AC定量分析和目视分析的正常率分别为95%、98%和98%(P=NS)。我们利用530c CZT相机建立了低剂量静息/负荷~(99)m四氧嘧啶心肌灌注SPECT的非AC和AC正常数据库。定量分析的每个患者的诊断性能与经验丰富的读者的目测分析没有显著差异。
We set out to develop normal databases and prospectively validate abnormality criteria for a low-dose Tc-99m tetrofosmin myocardial perfusion SPECT protocol using the 530c CZT camera.All patients received 6 mCi rest/20 mCi stress doses of Tc-99m tetrofosmin. Rest and stress images were obtained over 7-9 and 5-7 minutes according to the chest size. Low-dose CT of the chest was obtained on a standalone CT scanner. Forty patients with very low likelihood (LLK) of coronary artery disease (CAD) were used to define the normal count distributions. The abnormality criteria were prospectively validated in 55 patients who had coronary angiography and in 40 patients with LLK of CAD.The results for quantitative non-attenuation-corrected (AC) and AC analysis and visual analysis were as follows: sensitivity of 79%, 85%, and 92% (P = NS) and specificity of 44%, 75%, and 56% (P = NS), respectively. The normalcy rates for quantitative non-AC and AC analyses and visual analysis were 95%, 98%, and 98% (P = NS).We have developed non-AC and AC normal databases for low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT protocol using the 530c CZT camera. The per-patient diagnostic performance of quantitative analyses is not significantly different from visual analysis by an experienced reader.