Dyslipidemia and blood-brain barrier integrity in Alzheimer's disease.
Dyslipidemia and blood-brain barrier integrity in Alzheimer's disease.
复制标题
DOI：
10.1155/2012/184042
复制
发表时间：
2012
影响因子：
--
通讯作者：
Quinn JF
中科院分区：
文献类型：
--
作者：
Bowman GL;Kaye JA;Quinn JF
背景资料。血脑屏障(BBB)功能障碍可能在阿尔茨海默病(AD)的发病机制中起重要作用。与血脑屏障功能相关的可修饰因子可能具有治疗意义。本研究验证了轻中度AD患者血脂异常与血脑屏障损害相关的假说。方法：研究方法。对36例AD患者进行为期1年的随访。在基线和12个月时收集空腹脑脊液和血浆，并进行临床评估。血脑屏障损害定义为脑脊液白蛋白指数≥9。独立t检验和线性回归分析血浆脂蛋白与血脑屏障完整性的关系。结果。血脂异常在47%的人群中普遍存在，在血脑屏障受损的人群中占75%。血脑屏障受损患者的平均血浆甘油三酯显著高于正常对照组(P=0.007)，高密度脂蛋白显著低于正常对照组(P=0.043)。血浆甘油三酯可以解释血脑屏障完整性变化的22%，在控制了年龄、性别、载脂蛋白E-4基因、血压和他汀类药物的使用后，甘油三酯仍然显著。结论。血脂异常在伴有血脑屏障损害的AD患者中更为普遍。血浆甘油三酯和高密度脂蛋白胆固醇可能在维持轻至中度阿尔茨海默病患者的血脑屏障完整性方面发挥作用。
Background. Blood-brain barrier (BBB) dysfunction may have a significant role in the pathogenesis of Alzheimer's disease (AD). Modifiable factors associated with BBB function may have therapeutic implication. This study tested the hypothesis that dyslipidemia is associated with BBB impairment in mild-to-moderate AD. Methods. Thirty-six subjects with AD were followed for 1 year. Fasting CSF and plasma were collected with clinical assessments at baseline and 12 months. BBB impairment was defined as CSF albumin index ≥9. Independent t-tests and linear regression assessed the relationship between plasma lipoproteins and BBB integrity. Results. Dyslipidemia was prevalent in 47% of the population, and in 75% of those with BBB impairment. Subjects with BBB impairment had significantly higher mean plasma triglyceride and lower HDL cholesterol (TG, P = 0.007; HDL, P = 0.043). Plasma triglycerides explained 22% of the variance in BBB integrity and remained significant after controlling for age, gender, ApoE-4 genotype, blood pressure, and statin use. Conclusion. Dyslipidemia is more prevalent in AD subjects with BBB impairment. Plasma triglyceride and HDL cholesterol may have a role in maintaining BBB integrity in mild-to-moderate Alzheimer's disease.