Short synthesis of (+)-cylindricine c by using a catalytic asymmetric Michael reaction with a two-center organocatalyst
Short synthesis of (+)-cylindricine c by using a catalytic asymmetric Michael reaction with a two-center organocatalyst
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DOI：
10.1002/anie.200601722
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Shibuguchi, Tomoyuki;Mihara, Hisashi;Shibasaki, Masakatsu
（化学方程式）买一送一：（+）-柱孢菌素C的全合成采用催化不对称Michael反应和串联环化反应，经六步完成。一种新设计的双中心有机催化剂在此Michael反应中提供了良好的选择性。TaDiAS=酒石酸盐衍生的二铵盐。
(Chemical Equation Presented) Two for the price of one: The total synthesis of (+)-cylindricine C has been achieved in six steps using a catalytic asymmetric Michael reaction and tandem cyclization. A newly designed two-center organocatalyst gives good selectivity in this Michael reaction. TaDiAS= tartrate-derived diammonium salt.