The ffnfluence of sex steroids on Sjogren's syndrome
The ffnfluence of sex steroids on Sjogren's syndrome
复制标题
DOI：
10.1196/annals.1422.045
复制
发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Konttinen, Yrjo T.
中科院分区：
文献类型：
--
作者：
Porolao, Paulna;Laine, Mikael;Konttinen, Yrjo T.
干燥综合征是一种自身免疫性疾病，影响外分泌腺，最典型的是唾液腺和泪腺。在干燥综合征中，这些腺体的腺泡细胞被损坏和破坏，导致唾液和泪液分泌减少。因此，目前美国-欧洲的干燥综合征标准包括口干（口干）和干燥性角结膜炎（干眼）。除了这些干燥症状和体征，诊断标准还需要干燥综合征SS-A和/或SS-B自身抗体形式的自身免疫特征和唇唾液腺中的淋巴细胞浸润。大多数干燥综合征患者是女性，通常在40-50岁时进行诊断。干燥综合征的病因尚不清楚，但考虑到女性占优势和发病较晚，我们的假设是性类固醇在干燥综合征的病因中起关键作用。更具体地说，我们认为干燥综合征背后的驱动因素可能是缺乏雄激素。已经显示，与年龄匹配的健康对照相比，干燥综合征患者具有低浓度的循环硫酸脱氢表雄酮（DHEA-S）。我们的假设是干燥综合征患者由于DHEA-S激素原的低全身水平和/或无效的局部内分泌处理，在疾病的外分泌靶组织中局部雄激素作用不足。为了进一步阐明性类固醇的作用和雄激素的最终缺乏，使用由雄激素或雌激素调节的蛋白质标记物研究唾液腺。
Sjogren's syndrome is an autoimmune disease affecting the exocrine glands, most typically salivary and lacrimal glands. In Sjogren's syndrome, the acinar cells of these glands are damaged and destroyed, leading to diminished secretion of saliva and tear fluid. Accordingly, the current American-European criteria of Sjogren's syndrome include xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). In addition to these sicca symptoms and signs, the diagnostic criteria require autoimmune features in the form of Sjogren's syndrome SS-A and/or SS-B autoantibodies and lymphocyte infiltrates in labial salivary glands. Majority of patients with Sjogren's syndrome are women and the diagnosis is usually done when they are 40-50 years old. The cause of Sjogren's syndrome is unknown, but taking into account the female dominance and the late onset, our hypothesis is that sex steroids play a key role in the etiology of Sjogren's syndrome. More specifically, we believe that the driving factor behind Sjogren's syndrome could be lack of androgens. It has been shown that patients with Sjogren's syndrome have low concentrations of circulating dehydroepiandrosterone sulfate (DHEA-S) compared to age-matched healthy controls. Our hypothesis is that patients with Sjogren's syndrome suffer from an insufficient local androgen effect in the exocrine target tissues of the disease because of low systemic levels and/or ineffective local intracrine handling of DHEA-S prohormone. To further clarify the role of sex steroids and the eventual deficiency of androgens, salivary glands are studied using protein markers regulated by androgens or estrogens.