International Society for Biomedical Research on Alcoholism: relationship of cell necrosis and proliferation, free radicals and other agents to alcohol-related cancers.
International Society for Biomedical Research on Alcoholism: relationship of cell necrosis and proliferation, free radicals and other agents to alcohol-related cancers.
复制标题
国际酒精中毒生物医学研究协会：细胞坏死和增殖、自由基和其他因素与酒精相关癌症的关系。
DOI：
10.1007/bf01212730
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发表时间：
1993
影响因子：
3.6
通讯作者：
Mufti,SI
中科院分区：
文献类型：
--
作者：
Mufti,SI
酒精、烟草和饮食是人类癌症的三大危险因素。美国精神病学协会进行的一项以社区为基础的研究表明，美国大约13%的成年人在一生中的某个时候有酒精滥用和依赖。在其他一些国家，依赖酒精的人口比例甚至更大。国际酗酒问题生物医学研究学会（ISBRA）及其区域附属机构，包括欧洲对应机构ESBRA和美国酗酒问题研究学会（RSA）的介绍和讨论中强调了与酗酒有关的问题。区域附属机构通常每年举行会议，而ISBRA每隔一年在不同的国家举行一次会议。今年，国际建筑师协会会议在布里斯托（英国）举行，并于1992年6月18日至7月1日在波尔多（法国）和隆德（瑞典）举行了两次附属会议。本报告涉及在波尔多和布里斯托会议上讨论的与酒精和癌症有关的领域。由于流行病学研究表明长期饮酒与癌症风险之间存在密切联系，因此开发了动物模型来确定这种风险的机制。提出的一种机制表明，乙醇可以通过诱导细胞色素P-450系统的酶来调节致癌作用，细胞色素P-450系统将致癌物转化为其活性中间体，这是DNA反应性和致突变性的。另一种机制涉及乙醇对细胞损伤和细胞增殖的影响。乙醇具有细胞毒性，其存在导致细胞萎缩，随后是增殖细胞反应。HK Seitz（Heidelberg，FRG）在波尔多的会议上提供的数据表明，长期饮酒导致唾液腺实质萎缩和脂肪变性，这种情况与唾液分泌显著减少有关。他还发现
Alcohol, tobacco and diet are the three major human cancer risk factors. A community-based study carried out by the American Psychiatry Association showed that approximately 13% of the adult population in the United States has had alcohol abuse and dependence sometime in their life. The proportion of the population that is alcohol-dependent is even larger in some other countries. The problems associated with alcohol abuse are highlighted in presentations and discussions of the International Society for Biomedical Research on Alcoholism (ISBRA) and its regional affiliates including its European counterpart, ESBRA and the US Research Society on Alcoholism (RSA). Regional affiliates normally meet each year while ISBRA holds a conference in a different country every other year. This year the ISBRA conference was held at Bristol (England) with two satellite meetings at Bordeaux (France) and Lund (Sweden) from 18 June to 1 July 1992. This report deals with areas relating to alcohol and cancer that were discussed in the conferences at Bordeaux and Bristol.Since epidemiological studies have indicated a strong association between chronic alcohol consumption and cancer risk, animal models are developed to determine the mechanisms that underlie this risk. A mechanism proposed suggests that ethanol could modulate carcinogenesis by its ability to induce enzymes of the cytochrome P-450 system that convert pro-carcinogens to their reactive intermediates, which are DNA-reactive and mutagenic. Another mechanism involves the effect of ethanol on cell injury and cell proliferation. Ethanol is cytotoxic and its presence causes cell atrophy that is followed by a proliferative cell response. HK Seitz (Heidelberg, FRG) at the meeting in Bordeaux presented data indicating that chronic ethanol consumption led to an atrophy and lipomatic metamorphosis of the parenchyma of the salivary glands, a condition that is associated with a striking reduction in saliva secretion. He also found