Local inhibition of carbonic anhydrase does not decrease sweat rate
Local inhibition of carbonic anhydrase does not decrease sweat rate
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局部抑制碳酸酐酶不会降低出汗率
DOI：
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发表时间：
2018
影响因子：
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通讯作者：
M. Buono
中科院分区：
文献类型：
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作者：
Jeff M. Moore;S. Northway;N. Wells;E. Woolf;M. Buono
摘要背景：本研究的目的是通过经皮离子导入乙酰唑胺，直接抑制外泌汗腺中的碳酸酐酶（CA），以测定高温运动时的出汗率。假设如果CA对汗液产生很重要，则乙酰唑胺局部给药（无过去研究中通常相关的脱水的混杂全身效应）将对运动期间的出汗率产生显著影响。方法：10名健康受试者自愿接受前臂电离子导入乙酰唑胺或蒸馏水后进行高温运动。结果如下：在高温条件下，蒸馏水离子导入部位的平均出汗率为0.59±0.31 μL/cm 2/min，而乙酰唑胺离子导入部位的平均出汗率为0.63±0.36 μL/cm 2/min（p>0.05）。结论：本研究最重要的发现是，乙酰唑胺离子导入在高温下运动时并没有显著降低出汗率。这些结果表明，在过去的研究中，是全身性脱水，而不是在汗腺水平上的CA抑制，导致了报告的出汗率降低。
Abstract Background: The purpose of this study was to measure sweat rate during exercise in the heat after directly inhibiting carbonic anhydrase (CA) in eccrine sweat glands via transdermal iontophoresis of acetazolamide. It was hypothesized that if CA was important for sweat production, local administration of acetazolamide, without the confounding systemic effects of dehydration typically associated with past studies, would have a significant effect on sweat rate during exercise. Methods: Ten healthy subjects volunteered to exercise in the heat following acetazolamide or distilled water iontophoresis on the forearm. Results: The distilled water iontophoresis site had a mean sweat rate during exercise in the heat of 0.59±0.31 μL/cm2/min, while the acetazolamide iontophoresis site had a mean sweat rate of 0.63±0.36 μL/cm2/min (p>0.05). Conclusions: The most important finding of the current study was that iontophoresis of acetazolamide did not significantly decrease sweat rate during exercise in the heat. Such results suggest that in past studies it was systemic dehydration, and not CA inhibition at the level of the sweat gland, that caused the reported decreased sweat rate.