Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2
复制标题
DOI：
10.1016/j.mehy.2020.109893
复制
发表时间：
2020-10-01
影响因子：
4.7
通讯作者：
Alsibai, Kinan Drak
中科院分区：
文献类型：
--
作者：
Alsibai, Kinan Drak
最近，一个小型的审查发表在医学假设杂志上，题为2019-nCoVSARS-CoV-2（COVID-19）感染：弗林蛋白酶的关键性和与癌症的相关性。先前的研究已经指出，蛋白质的蛋白水解切割的破坏可以促进感染性和非感染性疾病。在过去的几周里，人们对SARS-CoV 2的病理生理学有了重要的发现。这种新型冠状病毒病（COVID-19）是一种高度接触和传播的急性呼吸道传染病。SARS-CoV-2由依赖RNA的RNA聚合酶和包括S蛋白在内的结构蛋白组成。有趣的是，FURIN，转化酶家族的前蛋白之一，在病毒糖蛋白的成熟中起着至关重要的作用。此外，包括冠状病毒在内的许多病毒利用FURIN来激活其糖蛋白。最近的数据表明，SARS-CoV-2通过与血管紧张素转换酶2结合进入人体细胞。随后，S蛋白在FURIN的帮助下被跨膜蛋白酶丝氨酸2切割，FURIN有助于病毒在结合后进入细胞。此外，FURIN似乎与SARS-CoV-2的发病机制有关，并可能与人传人率的增加有关。
Recently, a mini-review was published in the Medical Hypotheses journal by Usul Afsar entitled 2019-nCoVSARS-CoV-2 (COVID-19) infection: Cruciality of Furin and relevance with cancer. Previous studies have pointed out that disruption of the proteolytic cleavage of proteins can promote infectious and non-infectious diseases. The last few weeks have been marked by an important revelation concerning the pathophysiology of SARS-CoV2. This new coronavirus disease (COVID-19) is a highly contagious and transmissible acute respiratory infectious disorder. SARS-CoV-2 is composed of RNA-dependent RNA polymerase and structural proteins including Spike protein (S protein). Interestingly, the FURIN, one of the proproteins of the convertase family, plays a crucial role in the maturation of viral glycoproteins. In addition, many viruses including coronaviruses, exploit FURIN for the activation of their glycoproteins. Recent data indicate that SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2. Subsequently, the S protein is cleaved by transmembrane protease serine 2 with the help of FURIN which facilitates the entry of the virus into the cell after binding. Furthermore, it seems that FURIN is implicated in the pathogenesis of SARS-CoV-2 and potentially in the increased rates of human-tohuman transmission.