Biodistribution and clearance of liposomal gadolinium-DTPA.
Biodistribution and clearance of liposomal gadolinium-DTPA.
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DOI：
10.1097/00004424-199006000-00004
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发表时间：
1990-06
影响因子：
6.7
通讯作者：
E. Unger;D. Cardenas;A. Zerella;L. Fajardo;C. Tilcock
中科院分区：
文献类型：
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作者：
E. Unger;D. Cardenas;A. Zerella;L. Fajardo;C. Tilcock
Gd-DTPA(Gd-DTPA)脂质体作为肝脏造影剂已被研究过，并已被证明能改善对大鼠肝转移的检测。我们合成了包裹Gd-DTPA的100 nm和50 nm脂质体，并在大鼠体内进行了生物分布和清除研究。同时进行平行磁共振成像(MRI)研究。生物分布显示Gd-DTPA脂质体的血池相延长，100 nm脂质体的血池半衰期约为4小时。每克组织的摄取量最高的是脾。Gd在肝和脾中的清除半衰期为3-4天。较小的50 nm Gd-DTPA脂质体导致较长的血液期和更高的Gd-DTPA向肝脏、骨髓和脾的转运。静脉(IV)注射Gd-DTPA后的成像研究显示，器官增强与生物分布研究的数据相一致，在低至0.025 mm/kg的脂质体Gd-DTPA剂量下，肝脏有明显的增强。
Gadolinium-DTPA (Gd-DTPA) liposomes have been studied previously as liver contrast agents and have been shown to improve the detection of hepatic metastases in rats. We synthesized 100-nm and 50-nm liposomes that encapsulated Gd-DTPA and did biodistribution and clearance studies in rats. Parallel magnetic resonance imaging (MRI) studies were also done. Biodistribution showed a prolonged blood pool phase for Gd-DTPA liposomes with a blood pool half-life of approximately 4 hours for the 100-nm liposomes. The highest uptake per gram of tissue was achieved by the spleen. Clearance of gadolinium from the liver and spleen showed a half-life of 3 to 4 days. The smaller 50-nm Gd-DTPA liposomes resulted in a longer blood pool phase and a higher delivery of gadolinium to the liver, bone marrow, and spleen. Imaging studies after intravenous (IV) administration of liposomal Gd-DTPA showed organ enhancement that paralleled the data on biodistribution studies, with appreciable hepatic enhancement at doses as low as 0.025 mm/kg of liposomal Gd-DTPA.