A comparative study of MR extracellular volume fraction measurement and two-dimensional shear-wave elastography in assessment of liver fibrosis with chronic hepatitis B
A comparative study of MR extracellular volume fraction measurement and two-dimensional shear-wave elastography in assessment of liver fibrosis with chronic hepatitis B
复制标题
MR细胞外体积分数测量与二维剪切波弹性成像评估慢性乙型肝炎肝纤维化的对比研究
DOI：
10.1007/s00261-018-1860-1
复制
发表时间：
2019-04-01
影响因子：
2.4
通讯作者：
Sheng, Ruofan
中科院分区：
文献类型：
--
作者：
Jin, Kaipu;Wang, Heqing;Sheng, Ruofan
目的探讨MR肝脏细胞外容积（ECVliver）对慢性B肝炎（CHB）肝纤维化的评价价值，并与二维剪切波弹性成像（SWE）进行比较。所有患者均接受钆喷酸二甲胺增强T1标测和2D SWE。测量并比较纤维化亚组之间的ECVliver和肝硬度;使用斯皮尔曼相关性检验和多元回归分析评估其与组织学结果的相关性。结果ECVliver和肝硬度均随肝纤维化评分的增加而增加（F=17.08 ~ 10.99，P
ObjectiveTo evaluate the value of MR liver extracellular volume (ECVliver) in assessment of liver fibrosis with chronic hepatitis B (CHB), and to compare its performance with two-dimensional (2D) shear-wave elastography (SWE).Materials and methodsA total of 68 CHB patients who were histologically diagnosed as fibrosis stages F0 to F4 were retrospectively analyzed. All patients underwent gadopentetate dimeglumine-enhanced T1-mapping and 2D SWE. ECVliver and liver stiffness were measured and compared between fibrosis subgroups; their correlations with histologic findings were evaluated using Spearman correlation test and multiple regression analysis. Diagnostic performance in evaluating liver fibrosis stages was assessed and compared using receiver-operating characteristic analysis.ResultsBoth ECVliver and liver stiffness increased as the fibrosis score increased (F=17.08 to 10.99, P