MATERNALLY TRANSMITTED RESISTANCE TO LYMPHOMA DEVELOPMENT IN MICE OF RECIPROCAL CROSSES OF THE RF-J AND AKR-J STRAINS
MATERNALLY TRANSMITTED RESISTANCE TO LYMPHOMA DEVELOPMENT IN MICE OF RECIPROCAL CROSSES OF THE RF-J AND AKR-J STRAINS
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DOI：
10.1016/0092-8674(80)90517-6
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发表时间：
1980-01-01
期刊：
影响因子：
64.5
通讯作者：
LILLY, F
中科院分区：
文献类型：
--
作者：
MAYER, A;STRUUCK, FD;LILLY, F
低淋巴瘤的RF/J株的雌性而不是雄性在与高淋巴瘤的AKR/J株的F1杂交中传递抑制淋巴瘤发展的非孟德尔因子。抑制淋巴瘤也明显在1日回交一代父母AKR应变,但只有当(RF .female。同学们。AKR .male)。F1小鼠为雌性亲本。该母本耐药因子独立于RF株的显性、抑制淋巴瘤的Fv-1n等位基因的传播，但这两个因子的抑制能力似乎是加性的。在该杂交中，与互交F1杂交的小鼠相比，RF雌性F1后代也表现出对嗜生态小鼠白血病病毒表达的明显抑制，但在抑制淋巴瘤的AKR回交群体中未发现这种病毒表达的抑制。无嗜生态病毒抑制小鼠淋巴瘤的观察。AKR)F1 .女性.次。AKR.male。回交代表明在决定这两种效应时存在质或量上的差异。
Females but not males of the low-lymphoma RF/J strain transmit a non-Mendelian factor which suppresses the development of lymphoma in F1 crosses with mice of the high-lymphoma AKR/J strain. Suppression of lymphoma was also evident in the 1st backcross generation to the parental AKR strain, but only when (RF .female. .times. AKR .male.)F1 mice were the female parents. This maternal resistance factor was transmitted independently of the dominant, lymphoma-suppressing Fv-1n allele transmitted by males and females of the RF strain, but the suppressive capacities of the 2 factors appeared to be additive. In this cross, F1 progeny of RF females also showed marked suppression of ecotropic murine leukemia virus expression by comparison with mice of the reciprocal F1 cross, but this suppression of virus expression was not detected in the lymphoma-suppressed AKR backcross population. The observation of lymphoma suppression in the absence of ecotropic virus suppression in mice of the (RF .times. AKR)F1 .female. .times. AKR.male. backcross generation indicates a qualitative or quantitative difference in the determination of these 2 effects.