Baseline Characterization of Dengue Epidemiology in Yogyakarta City, Indonesia, before a Randomized Controlled Trial of Wolbachia for Arboviral Disease Control
Baseline Characterization of Dengue Epidemiology in Yogyakarta City, Indonesia, before a Randomized Controlled Trial of Wolbachia for Arboviral Disease Control
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DOI：
10.4269/ajtmh.18-0315
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Anders, Katherine L.
中科院分区：
文献类型：
--
作者：
Indriani, Citra;Ahmad, Riris A.;Anders, Katherine L.
登革热是印度尼西亚的地方病。在这里，我们描述了登革热的流行病学在城市的日惹，中爪哇，作为一个前奏，实施一个集群随机试验沃尔巴克氏体虫媒病毒传播的生物控制。2006年至2016年的监测记录显示，登革热发病率存在不同程度的季节性波动。两条证据表明感染力很高;过去十年中诊断为登革出血热或登革休克综合征的住院病例负担主要包括儿童/青少年，对314名1-10岁健康儿童的血清学调查发现，68%的人拥有登革病毒中和抗体。最后，一项行动能力调查表明，1至10岁的儿童，特别是1至5岁的儿童，白天大部分时间都呆在家里。这些发现为临床试验的设计提供了信息，以测量新型病媒控制方法的影响，例如Wolbachia渐渗到埃及伊蚊中，提供了有关疾病发病率的基线数据，并确定了用于招募登革病毒感染和疾病的前瞻性研究的亚群。流动性调查结果表明，在社区一级实施的干预措施的群集试验中，可以合理地预期，从流行病学角度来看，幼儿的大部分接触时间都在他们被随机分配的治疗组内度过。
Dengue is endemic in Indonesia. Here, we describe the epidemiology of dengue in the city of Yogyakarta, Central Java, as a prelude to implementation of a cluster-randomized trial of Wolbachia for the biocontrol of arboviral transmission. Surveillance records from 2006 to 2016 demonstrate seasonal oscillations of dengue incidence with varying magnitude. Two lines of evidence demonstrate a high force of infection; the hospitalized case burden of patients diagnosed with dengue hemorrhagic fever or dengue shock syndrome over the last decade consisted predominantly of children/adolescents, and a serosurvey of 314 healthy children aged 1-10 years found 68% possessed dengue virus-neutralizing antibodies. Finally, a mobility survey indicated children aged 1-10 years, and particularly 1-5 year-olds, spent most of their daytime hours at home. These findings inform the design of clinical trials to measure the impact of novel vector control methods such as Wolbachia introgression into Aedes aegypti mosquitoes, by providing baseline data on disease incidence and identifying subpopulations for recruitment into prospective studies of dengue virus infection and disease. The mobility survey findings indicate that in cluster trials of interventions applied at the community level, young children can reasonably be expected to spend most of their exposure time, in epidemiological terms, within the treatment arm to which they were randomized.