BIOMECHANICAL DESTRUCTION OF CANCER-CELLS IN SKELETAL-MUSCLE - A RATE-REGULATOR FOR HEMATOGENOUS METASTASIS
BIOMECHANICAL DESTRUCTION OF CANCER-CELLS IN SKELETAL-MUSCLE - A RATE-REGULATOR FOR HEMATOGENOUS METASTASIS
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DOI：
10.1007/bf01753809
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发表时间：
1989-09-01
影响因子：
4
通讯作者：
WEISS, L
中科院分区：
文献类型：
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作者：
WEISS, L
将小鼠左心室注射后，B16 黑色素瘤和艾利希腹水肿瘤细胞被捕获在股四头肌的微血管系统中。在递送后 5 分钟内，通过对去神经（放松）、非收缩或收缩肌肉进行生物测定来确定周围组织压力变化对被捕获细胞存活的影响。结果表明，癌细胞在去神经支配的肌肉中存活率最高，然后是非收缩性肌肉，而在电刺激的肌肉中存活率最低。结果与以下假设一致：大多数癌细胞在输送到至少一些靶器官后快速死亡是它们在微脉管系统内机械相互作用的结果。
Following left ventricular injection into mice, B16 melanoma and Ehrlich ascites tumor cells are arrested in the microvasculature of the quadriceps femoris muscles. Within 5 min of delivery the effects of variation in surrounding tissue pressure on the survival of the arrested cells have been determined by bioassays of denervated (relaxed), non-contracting or contracting muscle. The results show that cancer cell survival is greatest in denervated, then non-contracting muscle, and least in electrically stimulated muscle. The results are in accord with the hypothesis that the rapid death of most cancer cells after delivery to at least some target organs is a consequence of their mechanical interactions within the microvasculature.