A PROSPECTIVE-STUDY OF ALCOHOL-CONSUMPTION AND BONE-MINERAL DENSITY
A PROSPECTIVE-STUDY OF ALCOHOL-CONSUMPTION AND BONE-MINERAL DENSITY
复制标题
DOI：
10.1136/bmj.306.6891.1506
复制
发表时间：
1993-06-05
影响因子：
105.7
通讯作者：
BARRETTCONNOR, E
中科院分区：
文献类型：
--
作者：
HOLBROOK, TL;BARRETTCONNOR, E
目的研究饮酒对特定人群骨密度的影响。设计：骨密度的前瞻性研究，在1988-91年期间测量，在一个队列中，该队列提供了1973-5年期间前一周和前24小时的酒精摄入量和其他影响骨密度的因素的基线数据。背景：加州伯纳多牧场。受试者——182名男性和267名女性，年龄在45岁及以上，其中一半是随机选择的，一半是高脂血症患者，他们在一周内提供了酒精摄入量的基线信息。在这些受试者中，142名男性和220名女性在24小时内提供了酒精摄入量的信息。主要观察指标：桡骨轴、超远端手腕、股骨颈和腰椎的骨密度。结果：男性和女性被分开考虑，饮酒量的分位数被用来描述低、中、高的饮酒量。随着一周内酒精摄入量的增加，男性股骨颈的骨密度（根据年龄、体重指数、吸烟、锻炼和雌激素替代疗法进行调整）显著增加(p
Objectives-To study the effects of alcohol consumption on bone mineral density in a defined population.Design-Prospective study of bone mineral density, measured during 1988-91, in a cohort who had given baseline data on alcohol intake in the previous week and in the previous 24 hours and other factors affecting bone mineral density during 1973-5.Setting-Rancho Bernardo, California.Subjects-182 men and 267 women aged 45 and over at baseline, half having been randomly selected and half having been chosen for hyperlipidaemia, who gave baseline information on alcohol intake in one week. Of these subjects, 142 men and 220 women gave information on alcohol intake in 24 hours.Main outcome measures-Bone mineral density of the radial shaft, ultradistal wrist, femoral neck, and lumbar spine.Results-Men and women were considered separately, and the tertiles of alcohol consumption were used to delineate low, medium, and high values of alcohol intake. With increasing alcohol intake in one week, bone mineral density (adjusted for age, body mass index, smoking, taking exercise, and oestrogen replacement therapy in women) increased significantly in the femoral neck of men (p