Stromal Androgen Receptor in Prostate Cancer Development and Progression.
Stromal Androgen Receptor in Prostate Cancer Development and Progression.
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DOI：
10.3390/cancers9010010
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发表时间：
2017-01-22
期刊：
影响因子：
5.2
通讯作者：
Buchanan G
中科院分区：
文献类型：
--
作者：
Leach DA;Buchanan G
前列腺癌的发生和发展是上皮细胞和成纤维细胞/肌成纤维细胞之间复杂相互作用的结果，这是一系列受激素调节的动态过程。虽然雄激素通过雄激素受体（AR）的作用是前列腺癌生物学的一个公认的组成部分，但越来越明显的是，周围基质中AR信号的变化可以显著影响肿瘤细胞的行为。这反映在基质AR表达与患者结局之间强相关性的一致发现中。在这篇综述中，我们探讨了成纤维细胞/肌成纤维细胞和前列腺癌细胞在原发部位的AR信号之间的关系，并详细介绍了成纤维细胞AR信号的已知功能，作用和机制。我们总结了雄激素在间质中的作用如何显著影响疾病进展的循证总结。
Prostate cancer development and progression is the result of complex interactions between epithelia cells and fibroblasts/myofibroblasts, in a series of dynamic process amenable to regulation by hormones. Whilst androgen action through the androgen receptor (AR) is a well-established component of prostate cancer biology, it has been becoming increasingly apparent that changes in AR signalling in the surrounding stroma can dramatically influence tumour cell behavior. This is reflected in the consistent finding of a strong association between stromal AR expression and patient outcomes. In this review, we explore the relationship between AR signalling in fibroblasts/myofibroblasts and prostate cancer cells in the primary site, and detail the known functions, actions, and mechanisms of fibroblast AR signaling. We conclude with an evidence-based summary of how androgen action in stroma dramatically influences disease progression.