Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects
Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects
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DOI：
10.1111/j.1462-8902.2003.0342.x
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发表时间：
2004-07-01
影响因子：
5.8
通讯作者：
Kishi, R
中科院分区：
文献类型：
--
作者：
Saijo, Y;Kiyota, N;Kishi, R
目的：最近的研究表明C反应蛋白(CRP)水平升高与身体脂肪，尤其是内脏脂肪组织有关，但大多数研究是在体重指数(BMI)高于亚洲人的西方人身上进行的。目的：探讨体重指数(BMI)低于西方人的健康日本人的C反应蛋白(CRP)浓度、内脏肥胖指标、胰岛素抵抗综合征与颈动脉粥样硬化的关系。方法：通过人体测量、生物电阻抗分析和腹部CT检查，探讨肥胖与内脏肥胖参数和C反应蛋白(高敏感性)的关系，并通过超声检查检测胰岛素抵抗综合征的成分、白介素6(IL-6)、组织坏死因子-α(TNF-α)和颈总动脉内膜-中层厚度(IMT)。结果：在粗略回归分析中，C反应蛋白与肥胖指标显著相关。在调整了年龄、性别和吸烟因素后，内脏肥胖的参数(腰围、腰臀比和内脏脂肪组织堆积)与C反应蛋白的相关性要强于其他肥胖参数。IL-6、TNF-α与C反应蛋白无相关性。血压(BP)、代谢变量和CCA-IMT也与CRP显著相关。但是，在调整了年龄、性别、吸烟和BMI后，血压和高密度脂蛋白胆固醇(HDLc)显著相关。结论：在日本健康受试者中，CRP水平与内脏脂肪组织相关，与胰岛素抵抗综合征的成分显著相关。这些数据支持内脏脂肪组织在动脉粥样硬化炎症成分中的可能作用，内脏脂肪组织导致CRP升高的机制还需要进一步研究。
Aim: Recent studies have suggested that the elevated C-reactive protein (CRP) levels are associated with body fat, especially visceral adipose tissue, but most of them were investigated in Westerners who had higher body mass index (BMI) than Asians. To investigate the association between CRP concentrations, parameters of visceral obesity, the insulin resistance syndrome and carotid atherosclerosis in healthy Japanese who had a lower BMI than Westerners.Methods: We explored the relationships between fatness and visceral obesity parameters [by anthropometry, bioelectrical impedance analysis and abdominal computed tomography (CT)] and CRP (high sensitivity) and examined their associations with components of insulin resistance syndrome, interleukin-6 (IL-6), tissue necrosis factor-alpha (TNF-alpha) and intima-media thickness (IMT) of common carotid arteries (CCAs) by ultrasonograms in 116 healthy Japanese subjects.Results: In crude regression analyses, CRP was significantly associated with measures of obesity. After adjustment for age, gender and smoking, the association with CRP was stronger for parameters of visceral obesity (waist circumference, waist-to-hip ratio and visceral adipose tissue accumulation) than for other parameters of obesity. IL-6 and TNF-alpha were not associated with CRP. Blood pressure (BP), metabolic variables and CCA-IMT were also significantly associated with CRP. But, after being adjusted for age, gender, smoking and BMI, BP and high-density lipoprotein cholesterol (HDLc) were significantly associated.Conclusion: CRP level is associated with visceral adipose tissue and is significantly associated with the components of insulin resistance syndrome in healthy Japanese subjects. These data support a possible role of visceral adipose tissue in inflammation component of atherosclerosis, and further studies are needed to study the mechanism of CRP elevation caused by visceral adipose tissue.