Synapses in the central nervous system.
Synapses in the central nervous system.
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DOI：
10.1083/jcb.2.4.193
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发表时间：
1956-07-25
期刊：
影响因子：
--
通讯作者：
PALAY SL
中科院分区：
文献类型：
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作者：
PALAY SL
在大鼠的髓质、小脑皮层和大脑皮层中已经描述了许多不同的突触。所有这些都具有如下相同的基本精细结构：突触前和突触后细胞的限制膜紧密靠近，没有任何原生质在突触上的连续性。两个相对的膜被约200 a宽的间隙隔开，并显示局部增厚和密度增加的区域。2. 轴突的突触前扩张，即末端足或钮扣末端，包含线粒体集合和直径约200至650 a的小泡簇。虽然这些结构在突触生理学中的意义尚不清楚，但提出了两种观点：线粒体通过其酶活性和离子运输之间的关系参与突触的电现象；小的突触囊泡提供了生理证据所要求的突触神经体液放电的突触前亚细胞单位的形态学表征。
A number of different synapses have been described in the medulla, cerebellar cortex, and cerebral cortex of the rat. All of these possess the same fundamental fine structure as follows: 1. Close apposition of the limiting membranes of presynaptic and postsynaptic cells without any protoplasmic continuity across the synapse. The two apposed membranes are separated by a cleft about 200 A wide, and display localized regions of thickening and increased density. 2. The presynaptic expansion of the axon, the end-foot or bouton terminal, contains a collection of mitochondria and clusters of small vesicles about 200 to 650 A in diameter. Although the significance of these structures in the physiology of the synapse is still unknown, two suggestions are made: that the mitochondria, by means of the relation between their enzymatic activity and ion transport, participate in the electrical phenomena about the synapse; and that the small synaptic vesicles provide the morphological representation of the prejunctional, subcellular units of neurohumoral discharge at the synapse demanded by physiological evidence.