Biomechanical characterization of a chronic type a dissected human aorta
Biomechanical characterization of a chronic type a dissected human aorta
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DOI：
10.1016/j.jbiomech.2020.109978
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发表时间：
2020-09-18
影响因子：
2.4
通讯作者：
Mongrain, Rosaire
中科院分区：
文献类型：
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作者：
Amabili, Marco;Arena, Goffredo O.;Mongrain, Rosaire
主动脉夹层是最致命的心血管疾病之一。从一名73岁男性供体（未诊断出遗传性疾病）中取出慢性A型（斯坦福大学）夹层主动脉进行研究。主动脉在整个长度上呈现夹层，其上升部分的直径达到7.7 cm。胸降主动脉层分离后进行层特异性准静态和动态力学特性。机械测试显示内膜的生理（健康）行为以及中膜和外膜的一些机械异常。特别是，这两个层的静态刚度在较小的应变是三倍小于任何一个测量的12个健康的脊椎动物。当测试粘弹性时，外膜相对于大多数健康动脉在3 Hz下的动态刚度呈现较大的相对增加。与耗散相关的外膜损失因子处于健康动脉瘤测量值的下限。将中膜和外膜表现出的这些机械性能异常归因于继发于夹层慢性性质的严重重塑似乎是合理的。然而，不能排除在重塑之前存在一些机械异常。(c)2020爱思唯尔有限公司保留所有权利。
Aortic dissection is one of the most lethal cardiovascular diseases. A chronic Type A (Stanford) dissected aorta was retrieved for research from a 73-year-old male donor without diagnosed genetic disease. The aorta presented a dissection over the full length, and it reached a diameter of 7.7 cm in its ascending portion. The descending thoracic aorta underwent layer-specific quasi-static and dynamic mechanical characterizations after layer separation. Mechanical tests showed a physiological (healthy) behavior of the intima and some mechanical anomalies of the media and the adventitia. In particular, the static stiffness of both these layers at smaller strains was three times smaller than any one measured for twelve healthy aortas. When the viscoelastic properties were tested, adventitia presented a larger relative increase of the dynamic stiffness at 3 Hz with respect to most of the healthy aortas. The loss factor of the adventitia, which is associated with dissipation, was at the lower limit of those measured for healthy aortas. It seems reasonable to attribute these anomalies of the mechanical properties exhibited by the media and the adventitia to the severe remodeling secondary to the chronic nature of the dissection. However, it cannot be excluded that some of the mechanical anomalies were present before remodeling. (c) 2020 Elsevier Ltd. All rights reserved.