Tobacco smoking and alcohol consumption as risk factors for glioma: A case-control study in Melbourne, Australia
Tobacco smoking and alcohol consumption as risk factors for glioma: A case-control study in Melbourne, Australia
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DOI：
10.1136/jech.50.4.442
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发表时间：
1996-08-01
影响因子：
6.3
通讯作者：
Giles, GG
中科院分区：
文献类型：
--
作者：
Hurley, SF;McNeil, JJ;Giles, GG
目的-研究吸烟和饮酒与成人胶质瘤风险之间的可能联系。设计-这是一项基于人群的病例对照研究。使用逻辑回归分析估计相对风险（ICR）。背景-墨尔本，澳大利亚，参与者-这些包括416例受试者（166名妇女，250名男子），占符合条件者的66%;和422名对照组受试者结果：吸烟者患神经胶质瘤的风险没有增加，（RR 1.29，95% CI 0.95，1.75），校正年龄、参考日期和性别。男性的风险略有增加（RR 1.64，95%CI 1.1，2.45），但女性的风险并未增加（RR 0.99，95%CI 0.62，1.62）。对于男性来说，随着吸烟包年数的增加，风险并未增加，但吸烟少于10年的受试者的风险显着增加。对于所有的受试者来说，饮酒并没有增加风险（RR 0.96，95% CI 0.67，1.37），女性（RR 0.69，95% CI 0.4，1.15）或男性（RR 1.40，95% CI 0.81，2.43）.结论-这项研究并不支持烟草和酒精消费之间的联系，男性吸烟的风险模式似乎不一致具有因果作用，可能是由于偶然性、反应偏倚或不受控制的混杂。
Objective - To investigate possible associations between tobacco smoking and alcohol consumption and the risk of adult glioma. Design - This was a population based, case-control study. Relative risks (ICR) were estimated using logistic regression analysis.Setting - Melbourne, Australia,Participants - These comprised 416 case subjects (166 women, 250 men), 66% of those eligible; and 422 control subjects (170 women, 252 men), 43.5% of those potentially eligible.Results - There was no increase in risk of glioma with having ever smoked tobacco (RR 1.29, 95% CI 0.95, 1.75) for all subjects, adjusted for age, a reference date, and gender. There was a slight increase in risk for men (RR 1.64, 95% CI 1.1, 2.45), but not for women (RR 0.99, 95% CI 0.62, 1.62), For men, there was no increase in risk with increasing pack-years of cigarette smoking, but the risk was significantly increased in subjects wile had smoked for less than 10 years. There was no increase in risk associated with having ever drunk alcohol for all subjects (RR 0.96, 95% CI 0.67, 1.37), women (RR 0.69, 95% CI 0.4, 1.15) or men (RR 1.40, 95% CI 0.81, 2.43).Conclusions - This study does not support an association between either tobacco alcohol consumption and pattern of risk associated with tobacco smoking in men appears inconsistent with a causal role, and may be due to chance, response bias, or uncontrolled confounding.