On the origin of Metazoan adhesion receptors: cloning of integrin alpha subunit from the sponge Geodia cydonium.
On the origin of Metazoan adhesion receptors: cloning of integrin alpha subunit from the sponge Geodia cydonium.
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关于后生动物粘附受体的起源：从海绵 Geodia cydium 中克隆整合素 α 亚基。
DOI：
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发表时间：
1997
影响因子：
10.7
通讯作者：
W. Müller
中科院分区：
文献类型：
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作者：
Z. Pancer;M. Kruse;I. Müller;W. Müller
整合素是脊椎动物和高等无脊椎动物门中已知的重要受体。到目前为止，还没有证据表明最低级的后生动物——海绵（Porifera）中存在整合素。我们从海洋海绵 Geodia cydium (GCINTEG) 中分离并鉴定了编码整合素 α 亚基的 cDNA 克隆。开放阅读框编码 1,086 个残基 (118 kDa) 的多肽。胞内结构域的特征是序列 Tyr-Phe-x-Gly-Phe-Phe-x-Arg，该序列在一个残基上与整联蛋白 α 亚基的特征共有模式不同。我们得出的结论是，海绵是最古老的多细胞动物门，已经利用了细胞之间以及细胞与细胞外基质之间调节和控制相互作用所需的结构元素。
Integrins are prominent receptors known from vertebrates and the higher phyla of invertebrates. Until now, no evidence has been provided for the existence of integrins in the lowest Metazoa, the sponges (Porifera). We have isolated and characterized a cDNA clone encoding the alpha subunit of integrin from the marine sponge Geodia cydonium (GCINTEG). The open reading frame encodes a polypeptide of 1,086 residues (118 kDa). The intracellular domain features the sequence Tyr-Phe-x-Gly-Phe-Phe-x-Arg, which is different in one residue from the characteristic consensus pattern for integrin alpha subunits. We conclude that sponges, the oldest multicellular animal phylum, already utilize the structural elements which are required for a tuned and controlled interaction among cells, and between cells and the extracellular matrix.
普通水螅细胞表面细胞外基质结合蛋白的证据。
DOI：
10.3109/15419069409014202
发表时间：
1994
期刊：
Cell adhesion and communication
影响因子：
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作者：
Agbas,A;SarrasJr,MP
通讯作者：
SarrasJr,MP