Clinical features of patients with small cell lung cancer and idiopathic pulmonary fibrosis treated with chemotherapy or chemoradiotherapy.
Clinical features of patients with small cell lung cancer and idiopathic pulmonary fibrosis treated with chemotherapy or chemoradiotherapy.
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DOI：
10.1177/1753466620963866
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发表时间：
2020-01
影响因子：
4.3
通讯作者：
Kadowaki N
中科院分区：
文献类型：
--
作者：
Kanaji N;Shimizu J;Sakai K;Ueda Y;Miyawaki H;Watanabe N;Uemura T;Hida T;Inoue T;Watanabe N;Oohara Y;Dobashi H;Kato M;Kadowaki N
小细胞肺癌（SCLC）合并特发性肺纤维化（IPF）患者的临床特征尚未完全阐明。
对366例经病理证实的接受化疗或放化疗的SCLC患者的数据进行回顾性分析，以研究SCLC合并IPF的临床特征。
366例患者中共有97例被诊断为间质性肺病（ILD），其中75例为IPF。对于局限期疾病（LD）和广泛期疾病（ED），IPF患者的中位无进展生存期（PFS）和总生存期（OS）均明显短于非ILD患者。多因素分析显示，体能状态差、ED期以及存在IPF与较短的OS相关。IPF患者对一线治疗的有效率明显低于非ILD患者。IPF患者接受少于三个周期一线化疗的比例较高，这是生存期较差的一个因素。在IPF局限期患者中，与单纯化疗相比，放化疗与更长的PFS和OS相关。
在SCLC患者中，IPF的存在与较低的有效率以及较短的PFS和OS相关。即使在IPF患者中，也有一些适合放化疗的病例。
本文的综述可通过补充材料部分获取。
The clinical features of patients with small cell lung cancer (SCLC) and idiopathic pulmonary fibrosis (IPF) have not been fully elucidated. Data on 366 patients with pathologically confirmed SCLC who had been treated with chemotherapy or chemoradiotherapy were retrospectively analyzed to investigate the clinical features of SCLC with IPF. A total of 97 out of the 366 patients were diagnosed with interstitial lung disease (ILD), and 75 of them had IPF. For both the limited disease (LD) and extensive disease (ED) stages, the median progression-free survival (PFS) and overall survival (OS) were significantly shorter in the patients with IPF compared with non-ILD patients. A multivariate analysis showed that poor performance status, ED stage, and the presence of IPF were associated with shorter OS. The response rate to first-line therapy was significantly lower in patients with IPF compared with the non-ILD patients. The rate of patients receiving fewer than three cycles of first-line chemotherapy was higher in patients with IPF, which was a factor of poor survival. In LD-stage patients with IPF, chemoradiotherapy was associated with longer PFS and OS compared with chemotherapy only. In patients with SCLC, the presence of IPF was associated with a lower response rate as well as shorter PFS and shorter OS. There are some cases that are suitable for chemoradiotherapy, even among patients with IPF. The reviews of this paper are available via the supplemental material section.
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