CMOS Biosensor IC Focusing on Dielectric Relaxations of Biological Water With 120 and 60 GHz Oscillator Arrays
CMOS Biosensor IC Focusing on Dielectric Relaxations of Biological Water With 120 and 60 GHz Oscillator Arrays
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DOI：
10.1109/jssc.2016.2605001
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发表时间：
2016-11-01
影响因子：
5.4
通讯作者：
Fujishima, Minoru
中科院分区：
文献类型：
--
作者：
Mitsunaka, Takeshi;Sato, Daiki;Fujishima, Minoru
提出了一种以120 GHz和60 GHz振荡器阵列为核心的生物水介电弛豫的CMOS生物传感器集成电路。为了实现无标记生物传感，我们专注于100 GHz附近的频率，在这些频率处，随着许多水分子与生物分子结合，水的介电常数的变化变得显著。为了检测生物水的状态，基于工作在120 GHz和60 GHz的LC振荡器的传感元件采用65 nm的CMOS工艺实现。传感元件的尺寸明显小于工作频率的波长，因此可以在芯片上实现二维阵列。试验芯片使我们能够获得目标的空间分布。本文对培养的细菌菌落生长进行了监测，并解释了其他生物传感器的应用，展示了使用生物传感器IC的可能性。
In this paper, a CMOS biosensor integrated circuit (IC) focusing on dielectric relaxations of biological water with 120 and 60 GHz oscillator arrays is proposed. To realize label-free biosensing, we focus on frequencies around 100 GHz where changes in the dielectric constant of water become prominent as many a water molecule is bound to biomolecules. To detect the state of the biological water, sensing elements based on LC-oscillators operating at 120 and 60 GHz are realized using the 65 nm CMOS process. The sizes of the sensing elements are significantly smaller than the wavelengths of the operating frequencies, therefore 2-D arrays can be implemented in a chip. The trial chip enables us to obtain spatial distributions of the targets. In this paper, the cultivated bacterial colony growth is monitored and other biosensing applications are explained, which showcase possibilities for using the biosensor IC.