Does the immobilizing effect of thiopental in brain exceed that of halothane?
Does the immobilizing effect of thiopental in brain exceed that of halothane?
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DOI：
10.1097/00000542-200204000-00028
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发表时间：
2002-04-01
期刊：
影响因子：
8.8
通讯作者：
Atherley, R
中科院分区：
文献类型：
--
作者：
Antognini, JF;Carstens, E;Atherley, R
背景资料。最近的研究表明，像异氟醚这样的麻醉剂在脊髓中起作用，以抑制在有害刺激期间发生的运动。作者使用差别麻醉给药模型研究了氟烷和硫喷妥钠对抑制伤害性运动的影响。他们假设氟烷和硫喷妥，类似于异氟醚，主要通过脊髓的作用抑制运动。方法：山羊被麻醉，并准备进行差别麻醉。麻醉维持用氟烷(n=5)或硫喷妥钠(n=5)。结果：对照(全身)氟烷用量为0.9+/-0.2%，差别给药时头部用量为3.4+/-1%(P<；0.01)。在选择性氟烷注射过程中，即使动物在有害刺激下活动，脑电也会受到极大的抑制或呈等电状态。对照组(全身)血浆硫喷妥钠需要量为20+/-10µg/ml，选择性头部注射硫喷妥钠后，5只动物脑电均活跃，头颅硫喷妥钠需要量为42+/-6µg/ml(P<；0.01)。结论：氟烷和硫喷妥钠与异氟醚一样作用于脊髓，抑制伤害性刺激引起的运动。然而，脑电数据表明，氟烷在大脑中的效力似乎较低，这表明氟烷在脊髓中的作用比硫喷妥钠更重要。
Background. Recent studies suggest that anesthetics such as isoflurane act in the spinal cord to suppress movement that occurs during noxious stimulation. The authors examined the effect of halothane and thiopental on suppression of noxious-evoked movement using a model of differential anesthetic delivery. They hypothesized that halothane and thiopental, similar to isoflurane, would suppress movement primarily via an action in spinal cord.Methods: Goats were anesthetized and prepared for differential anesthetic delivery. Anesthesia was maintained with halothane (n = 5) or thiopental (n = 5). Anesthetic requirements were determined (noxious clamp on a dewclaw for 1 min) during halothane or thiopental (via infusion) delivery to the whole body and delivery only to the head.Results: Control (whole body) halothane requirement was 0.9 +/- 0.2%; halothane requirement in the head during differential delivery was 3.4 +/- 1% (P < 0.01). During selective halothane delivery, the electroencephalogram was greatly depressed or was isoelectric even though the animals moved during noxious stimulation. Control (whole body) plasma thiopental requirement was 20 +/- 10 mug/ml. When thiopental was selectively delivered to the head, the electroencephalogram was active in all five animals, and cranial thiopental requirement was 42 +/- 6 mug/ml (P < 0.01).Conclusion: These data suggest that halothane and thiopental, like isoflurane, act in spinal cord to suppress movement occurring with noxious stimulation. However, halothane appears to be less potent in the brain as evidenced by the electroencephalogram data, suggesting that action in spinal cord plays a more significant role for halothane than for thiopental.