Metabolism and breast cancer risk: frontiers in research and practice.
Metabolism and breast cancer risk: frontiers in research and practice.
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DOI：
10.1016/j.jand.2012.08.015
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发表时间：
2013-02
影响因子：
4.8
通讯作者：
Cadmus-Bertram, Lisa A.
中科院分区：
文献类型：
--
作者：
Patterson, Ruth E.;Rock, Cheryl L.;Kerr, Jacqueline;Natarajan, Loki;Marshall, Simon J.;Pakiz, Bilge;Cadmus-Bertram, Lisa A.
50年前，癌症的病因在很大程度上是未知的。从那时起，肥胖与许多癌症，特别是绝经后乳腺癌之间存在着密切的关系。理解肥胖和癌症风险之间联系的一个主要挑战是阐明这种联系背后的生物学基础。尽管这一问题尚未解决，但将肥胖与癌症风险联系起来的主要候选系统是（1）胰岛素和胰岛素样生长因子-I（IGF-I）轴，（2）内源性生殖激素，以及（3）慢性炎症。本文的目的是提供一个机制的概述之间的假设关系的饮食，体力活动，肥胖与乳腺癌的风险和进展。此外，我们将提供最近资助的随机临床试验的例子，检查与乳腺癌风险和生存率有关的代谢危险因素。需要进行更多的研究来验证饮食、这些生物标志物和乳腺癌风险之间关系的强度和一致性。随着这些关系变得更加清晰，未来的研究将需要制定有效的干预计划，通过促进健康的生活方式来预防乳腺癌和改善癌症预后。
Fifty years ago, the causes of cancer were largely unknown. Since then, it has become clear that a strong relationship exists between obesity and many cancers, particularly postmenopausal breast cancer. A major challenge in understanding the link between obesity and cancer risk has been elucidating the biological basis underlying the association. Although this remains unresolved, the main candidate systems linking adiposity and cancer risk are (1) insulin and the insulin-like growth factor-I (IGF-I) axis, (2) endogenous reproductive hormones, and (3) chronic inflammation. The purpose of this paper is to provide a mechanistic overview of the hypothesized relationship between diet, physical activity, and obesity with breast cancer risk and progression. In addition, we will provide examples of recently funded randomized clinical trials examining metabolic risk factors in relation to breast cancer risk and survival. Additional research is warranted to validate the strength and consistency of the relationships among diet, these biomarkers, and breast cancer risk. As these relationships become clearer, future studies will be needed to develop effective intervention programs to prevent breast cancer and improve cancer prognosis by promoting a healthy lifestyle.
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DOI：
10.1097/ede.0b013e31824596a1
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bradshaw PT;Ibrahim JG;Stevens J;Cleveland R;Abrahamson PE;Satia JA;Teitelbaum SL;Neugut AI;Gammon MD
通讯作者：
Gammon MD
影响因子：
--
作者：
Alonzo, Todd A.;Siegmund, Kimberly D.
通讯作者：
Siegmund, Kimberly D.
影响因子：
3.6
作者：
Calder, Philip C.;Ahluwalia, Namanjeet;Winklhofer-Roob, Brigitte M.
通讯作者：
Winklhofer-Roob, Brigitte M.
影响因子：
4
作者：
Cirillo, Donatella;Rachiglio, Anna Maria;Normanno, Nicola
通讯作者：
Normanno, Nicola
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ