Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage
Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage
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DOI：
10.1016/j.jocn.2005.12.022
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发表时间：
2007-05-01
影响因子：
2
通讯作者：
Lin, Ching-Yuang
中科院分区：
文献类型：
--
作者：
Fang, Hsin-Yuan;Ko, Wen-Je;Lin, Ching-Yuang
诱导型热休克蛋白70（HSP 70）是一种在中枢神经系统中检测到的应激蛋白，当细胞或生物体处于应激状态时表达。白细胞介素-18（IL-18）和肿瘤坏死因子α（TNF-α）是多潜能的早期促炎细胞因子。我们的目的是确定自发性脑出血（ICH）患者血浆和CSF中HSP 70、IL-18和TNF-α的蛋白水平以及HSP 70、IL-18和TNF-α的mRNA水平，并将其与疾病结局相关联。对43名患者（平均年龄64 ± 9岁; 23名男性和20名女性）进行了CSF和血浆中蛋白质以及外周血单核细胞中mRNA的系列测量。10例（23%）患者死亡。我们发现，受损的大脑释放TNF-α和HSP 70到外周血，这些血浆水平与自发性ICH患者的死亡率高度相关。(C)2006爱思唯尔有限公司版权所有。
Inducible heat shock protein 70 (HSP70), a stress protein detected in the central nervous system, is expressed when a cell or organism is under stress. Interleukin-18 (IL-18) and tumor necrosis factor alpha (TNF-alpha) are multipotential early proinflammatory cytokines. Our objective was to determine protein levels of HSP70, IL-18, and TNF-alpha as well as mRNA levels of HSP70, IL-18, and TNF-alpha in the plasma and CSF of spontaneous intracerebral hemorrhage (ICH) patients, and to correlate these with disease outcome. Serial measurement of the proteins in CSF and plasma and of the mRNAs in peripheral blood mononuclear cells was conducted in 43 patients (mean age, 64 +/- 9 years; 23 men and 20 women). Ten (23%) patients died. We found that the damaged brain releases TNF-alpha and HSP70 to the peripheral blood and that plasma levels of these are highly associated with mortality in spontaneous ICH patients. (C) 2006 Elsevier Ltd. All rights reserved.