Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement
Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement
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DOI：
10.1016/j.phrs.2014.10.007
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发表时间：
2015-01-01
影响因子：
9.3
通讯作者：
Corder, Mario D.
中科院分区：
文献类型：
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作者：
Bullon, Pedro;Roman-Malo, Lourdes;Corder, Mario D.
氧化应激与几种传染病有关。在这方面，脂多糖（LPS），内毒素成分，诱导线粒体功能障碍和氧化应激在几个病理事件，如牙周病或败血症。在我们的实验中，LPS处理的成纤维细胞引起增加的氧化应激，线粒体功能障碍，减少耗氧量和线粒体生物合成。在比较辅酶Q（10）（CoQ（10））和N-乙酰半胱氨酸（NAC）之后，我们观察到CoQ（10）比NAC具有更显著的保护作用，这分别与其他亲脂性和亲水性抗氧化剂如维生素E或BHA相当。辅酶Q（10）通过激活PGC-1 α和TFAM改善线粒体生物合成。这种亲脂性抗氧化保护作用在LPS注射后的小鼠中观察到。这些结果表明，靶向抗氧化剂可能是一个可能的具体的治疗策略，在药理学治疗感染性疾病及其并发症。(C)2014爱思唯尔有限公司版权所有。
Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q(10) (CoQ(10)) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ(10) than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ(10) improved mitochondrial biogenesis by activating PGC-1 alpha and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications. (C) 2014 Elsevier Ltd. All rights reserved.