Arterial destiffening with weight loss in overweight and obese middle-aged and older adults.
Arterial destiffening with weight loss in overweight and obese middle-aged and older adults.
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DOI：
10.1161/hypertensionaha.109.147850
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发表时间：
2010-04
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影响因子：
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通讯作者：
Davy KP
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文献类型：
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作者：
Dengo AL;Dennis EA;Orr JS;Marinik EL;Ehrlich E;Davy BM;Davy KP
我们测试了一个假设，即通过低热量饮食减肥可以减少超重和肥胖的中老年人的动脉僵硬。36人随机分为减重组（n=25，年龄：61.2±0.8岁，体重指数：30.0±0.6 kg/m2）和对照组（n=11，年龄：66.1±1.9岁，体重指数：31.8±1.4 kg/m2）。在基线和干预12周后，通过颈动脉超声联合压扁血压计测量动脉硬度，并通过压扁血压计测量颈-股脉波速度。两组患者的体重、体脂、腹脂、血压、β-僵硬指数、颈-股脉波速度在基线时相似（均P < 0.05）。体重（- 7.1±0.7 kg vs - 0.7±1.1 kg）、体脂和腹部脂肪在减肥组下降，而在对照组没有（均P<0.05）。只有减重组肱动脉收缩压和舒张压下降（P<0.05）。两组中央收缩压和脉压均无明显变化。减肥组β-僵硬指数（- 1.24±0.22比0.52±0.37 U）和颈-股脉波速度（- 187±29比15±42 cm/s）下降，对照组无明显差异（均P<0.05）。颈股脉波速度降低与全身及腹部脂肪减少相关（r=0.357 ~ 0.602，均P<0.05）。然而，无论是全身肥胖还是腹部肥胖，都不能独立预测动脉僵硬指数的降低。总之，我们的研究结果表明，体重减轻可以降低超重/肥胖中老年人的动脉僵硬度，这些改善的程度与总脂肪和腹部脂肪的减少有关。
We tested the hypothesis that weight loss via a hypocaloric diet would reduce arterial stiffness in overweight and obese middle-aged and older adults. Thirty-six individuals were randomly assigned to a weight loss (n=25; age: 61.2±0.8 years; body mass index: 30.0±0.6 kg/m2) or a control (n=11; age: 66.1±1.9 years; body mass index: 31.8±1.4 kg/m2) group. Arterial stiffness was measured via carotid artery ultrasonography combined with applanation tonometry and carotid-femoral pulse wave velocity via applanation tonometry at baseline and after the 12-week intervention. Body weight, body fat, abdominal adiposity, blood pressure, β-stiffness index, and carotid-femoral pulse wave velocity were similar in the 2 groups at baseline (all P>0.05). Body weight (−7.1±0.7 versus −0.7±1.1 kg), body fat, and abdominal adiposity decreased in the weight loss group but not in the control group (all P<0.05). Brachial systolic and diastolic blood pressures declined (P<0.05) only in the weight loss group. Central systolic and pulse pressures did not change significantly in either group. β-Stiffness index (−1.24±0.22 versus 0.52±0.37 U) and carotid-femoral pulse wave velocity (−187±29 versus 15±42 cm/s) decreased in the weight loss group but not in the control group (all P<0.05). The reductions in carotid-femoral pulse wave velocity were correlated with reductions in total body and abdominal adiposity (r=0.357– 0.602; all P<0.05). However, neither total body nor abdominal adiposity independently predicted reductions in arterial stiffness indices. In summary, our findings indicate that weight loss reduces arterial stiffness in overweight/obese middle-aged and older adults, and the magnitudes of these improvements are related to the loss of total and abdominal adiposity.