On the Structure of Solid Lipid Nanoparticles
On the Structure of Solid Lipid Nanoparticles
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DOI：
10.1002/smll.201903156
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发表时间：
2019-09-18
期刊：
影响因子：
13.3
通讯作者：
Lorenz, Christian D.
中科院分区：
文献类型：
--
作者：
Pink, Demi L.;Loruthai, Orathai;Lorenz, Christian D.
固体脂质纳米粒（SLN）具有通过界面表面活性剂稳定的结晶脂质核心。SLN被认为是药物递送载体的有利候选物，因为它们储存和释放有机分子的能力可以通过所使用的脂质和表面活性剂的身份来定制。当储存时，载药SLN核心中的多晶型转变导致药物分子的过早释放。已经进行了重要的实验研究，目的是调查SLN的物理化学性质，然而，没有分子尺度的调查报告的行为，驱动SLN的形成和他们的多态性转变。因此，小角中子散射和全原子分子动力学模拟的组合用于产生包含甘油三酯、三棕榈精和非离子表面活性剂Brij O10（C18：1E10）的SLN的内部结构的详细原子描述。揭示了表面活性剂稳定SLN脂质核心晶体结构的分子尺度机制。通过将这些结果与三棕榈酸甘油酯脂质的模拟液体和固体聚集体进行比较，证明了这些系统之间脂质的形态如何变化，从而进一步了解控制药物包封和从SLN释放的机制。
Solid lipid nanoparticles (SLNs) have a crystalline lipid core which is stabilized by interfacial surfactants. SLNs are considered favorable candidates for drug delivery vehicles since their ability to store and release organic molecules can be tailored through the identity of the lipids and surfactants used. When stored, polymorphic transitions in the core of drug-loaded SLNs lead to the premature release of drug molecules. Significant experimental studies have been conducted with the aim of investigating the physicochemical properties of SLNs, however, no molecular scale investigations have been reported on the behaviors that drive SLN formation and their polymorphic transitions. A combination of small angle neutron scattering and all-atom molecular dynamics simulations is therefore used to yield a detailed atomistic description of the internal structure of an SLN comprising triglyceride, tripalmitin, and the nonionic surfactant, Brij O10 (C18:1E10). The molecular scale mechanisms by which the surfactants stabilize the crystalline structure of the SLN lipid core are uncovered. By comparing these results to simulated liquid and solid aggregates of tripalmitin lipids, how the morphology of the lipids vary between these systems is demonstrated providing further insight into the mechanisms that control drug encapsulation and release from SLNs.