Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss.
Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss.
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DOI：
10.1097/mpa.0000000000000974
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发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Xu M;Jung X;Hines OJ;Eibl G;Chen Y
目前，胰腺癌还没有有效的预防策略。肥胖已被越来越多地认为是胰腺癌的一个强大但可改变的风险因素。在这篇文章中，我们的目的是审查有关的文献减肥对预防胰腺癌。流行病学和实验室研究表明，肥胖与胰腺癌的发病率增加和潜在的更糟糕的癌症结局有关。尽管潜在的病理机制尚不清楚，但慢性炎症、胰岛素抵抗和肠道微生物群改变都与肥胖的致癌作用有关。减肥，特别是减肥手术后持久而显著的减肥，已被证明可以降低多种癌症的风险，并可能成为预防胰腺癌的良好干预措施。
Currently there are no effective preventive strategies for pancreatic cancer. Obesity has been increasingly recognized as a strong but modifiable risk factor of pancreatic cancer. In this article, we aim to review the literature regarding weight loss on prevention of pancreatic cancer. Epidemiological and laboratory studies have shown that obesity is associated with increased incidence of pancreatic cancer and potentially worse cancer outcome. Whereas the underlying pathomechanisms remain unclear, chronic inflammation, insulin resistance and altered intestinal microbiota are all implicated in the carcinogenic effect of obesity. Weight loss, especially the durable and significant weight loss after bariatric surgery, has been shown to reduce the risks of multiple cancers and may become a good intervention for pancreatic cancer prevention.