General homeostasis of the frequency of circadian oscillations.
General homeostasis of the frequency of circadian oscillations.
复制标题
昼夜节律振荡频率的一般稳态。
DOI：
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发表时间：
1973
影响因子：
11.1
通讯作者：
P. Caldarola
中科院分区：
文献类型：
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作者：
C. Pittendrigh;P. Caldarola
一些明确的统计规律描述了蟑螂昼夜节律振荡在大温度阶跃下的周期（tau）变化。这些可以用众所周知的昼夜节律振荡 tau 蛋白的温度补偿（稳态）来解释。在已发表的关于影响其他几种昼夜节律振荡的其他几个变量的影响的数据中也可以检测到相同的规律。然后提出这样的命题：面对细胞中可能遇到的所有变化，tau 蛋白的温度补偿只是昼夜节律振荡频率的一般稳态守恒的一个特例。 tau 蛋白的这种总体稳态是振荡器发挥有用“时钟”作用的功能先决条件。
Some well-defined statistical regularities characterize the change in period (tau) of cockroach circadian oscillations subjected to a large temperature step. These are explainable in terms of the well-known temperature-compensation (homeostasis) of tau of circadian oscillations. The same regularities are detectable in published data on the effect of several other variables affecting several other circadian oscillations. The proposition is then developed that the temperature-compensation of tau is only a special case of a general homeostatic conservation of the frequency of circadian oscillations in the face of all changes they are likely to encounter in the cell. Such a general homeostasis of tau is a functional prerequisite for an oscillator to function as a useful "clock."