Tryptase, a novel link between allergic inflammation and fibrosis
Tryptase, a novel link between allergic inflammation and fibrosis
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DOI：
10.1016/s1471-4906(03)00058-9
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发表时间：
2003-04-01
影响因子：
16.8
通讯作者：
Piliponsky, AM
中科院分区：
文献类型：
--
作者：
Levi-Schaffer, F;Piliponsky, AM
过敏是一种复杂的炎症性疾病，其病因是明确的。最近有人提出，嗜酸性粒细胞，肥大细胞和成纤维细胞的相互作用有助于变态反应的延续。此外，肥大细胞衍生的类胰蛋白酶可能作为这些细胞之间的联系。这一假说得到了最近两篇论文的支持，这两篇论文表明类胰蛋白酶似乎通过蛋白酶激活的受体-2介导气道中嗜酸性粒细胞浸润和依赖于环氧合酶和前列腺素合成的成纤维细胞增殖。
Allergy is a complex inflammatory disease, the etiology of which is well defined. It has recently been proposed that eosinophil, mast-cell and fibroblast interactions contribute to allergy perpetuation. Moreover, mast-cell-derived tryptase might act as a link among these cells. This hypothesis is supported by two recent papers that show that tryptase, seemingly through the protease-activated receptor-2, mediates eosinophil infiltration in the airways and fibroblast proliferation that depends on both cyclooxygenase and prostaglandin synthesis.