Risk of Healthcare-Associated Transmission of Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Hospitalized Cancer Patients.
Risk of Healthcare-Associated Transmission of Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Hospitalized Cancer Patients.
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DOI：
10.1093/cid/ciab670
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发表时间：
2022-05-03
期刊：
影响因子：
--
通讯作者：
Kamboj M
中科院分区：
文献类型：
--
作者：
Chow K;Aslam A;McClure T;Singh J;Burns J;McMillen T;Jani K;Lucca A;Bubb T;Robilotti EV;Babady NE;Kamboj M
关于高风险住院患者在非疫情环境中接触受感染患者或医护人员（HCW）后患2019年医院获得性冠状病毒病（COVID-19）的风险信息有限。本研究于2020年3月10日至2021年2月28日在纽约市的三级癌症中心进行。2020年4月上旬，研究机构在入院时实施了SARS-CoV-2通用检测，并在住院期间每3天进行一次复检。审查了所有接触SARS-CoV-2阳性患者和HCW的接触者追踪记录。从2020年3月10日至2021年2月28日，11348名在入院时为SARS-CoV-2聚合酶链反应（PCR）阴性的独特患者在住院期间接受了31662次入院后检测，其中112人检测阳性（0.98%）。其中，49名患者在入院期间住在半私人房间，导致74名密切接触者和14名继发感染者在14天内感染，总发病率为18.9%。在那些暴露于正在进行气溶胶生成程序（AGP）的室友中，发病率为35.7%。全基因组测序（WGS）证实了6/8对评估对的传播。此外，在214名患者中发生了3起传播事件，这些患者与105名COVID-19阳性医护人员（1.4%）有重大接触。住院癌症患者的医院获得性COVID-19的总体风险较低，即使在社区流行率高的时期也是如此。然而，与未被识别的情况下，共享占用与暴露的室友的二次发作率高。在与感染患者或医护人员（HCW）直接接触后，患者感染医院获得性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的风险较低。在暴露于气溶胶生成程序的共用房间期间有更大的传播风险。当社区发病率低时，不需要进行常规检测。
There is limited information on the risk of hospital-acquired coronavirus disease 2019 (COVID-19) among high-risk hospitalized patients after exposure to an infected patient or healthcare worker (HCW) in a nonoutbreak setting. This study was conducted at a tertiary care cancer center in New York City from 10 March 2020 until 28 February 2021. In early April 2020, the study institution implemented universal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing at admission and retesting every 3 days through the hospital stay. Contact tracing records were reviewed for all exposures to SARS-CoV-2 positive patients and HCWs. From 10 March 2020 to 28 February 2021, 11 348 unique patients who were SARS-CoV-2 polymerase chain reaction (PCR) negative at the time of admission underwent 31 662 postadmission tests during their hospitalization, and 112 tested positive (0.98%). Among these, 49 patients housed in semiprivate rooms during admission resulted in 74 close contacts and 14 secondary infections within 14 days, for an overall attack rate of 18.9%. Among those exposed to a roommate undergoing an aerosol-generating procedure (AGP), the attack rate was 35.7%. Whole genome sequencing (WGS) corroborated transmission in 6/8 evaluated pairs. In addition, three transmission events occurred in 214 patients with significant exposure to 105 COVID-19 positive healthcare workers (1.4%). The overall risk of hospital-acquired COVID-19 is low for hospitalized cancer patients, even during periods of high community prevalence. However, shared occupancy with an unrecognized case is associated with a high secondary attack rate in exposed roommates. There was low risk of hospital-acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients after direct contact with infected patients or healthcare workers (HCW). There was greater transmission risk during shared room occupancy with exposure to aerosol-generating procedures. Routine testing is not necessary when community rates are low.
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影响因子：
11.8
作者：
Rickman, Hannah M.;Rampling, Tommy;Houlihan, Catherine F.
通讯作者：
Houlihan, Catherine F.
影响因子：
13.8
作者：
Kluytmans-van Den Bergh, Marjolein F. Q.;Buiting, Anton G. M.;Kluytmans, Jan A. J. W.
通讯作者：
Kluytmans, Jan A. J. W.
气溶胶生成程序和将急性呼吸道感染传播给医疗保健工作者的风险：系统评价。
影响因子：
3.7
作者：
Tran K;Cimon K;Severn M;Pessoa-Silva CL;Conly J
通讯作者：
Conly J
影响因子：
4.5
作者：
Ariza-Heredia EJ;Frenzel E;Cantu S;Carlson M;Thomas G;Khawaja F;Raad II;Chemaly RF
通讯作者：
Chemaly RF
影响因子：
6.9
作者：
Wong, S. C. Y.;Kwong, R. T-S;Lung, D. C.
通讯作者：
Lung, D. C.