BUMETANIDE - POTENT NEW LOOP DIURETIC
BUMETANIDE - POTENT NEW LOOP DIURETIC
复制标题
DOI：
10.1136/bmj.1.5794.211
复制
发表时间：
1972-01-01
影响因子：
--
通讯作者：
GATENBY, PBB
中科院分区：
文献类型：
--
作者：
ASBURY, MJ;BOURKE, E;GATENBY, PBB
布美他尼是一种新型利尿剂，在27例受试者中进行了评价。其起效时间在30分钟内，90分钟达到峰值，总作用时间约为270分钟。在一项水肿患者的对照研究中，它与四十分之一摩尔剂量的速尿等效，并且在电解质排泄模式方面与速尿没有差异。连续口服给药8天，可产生有效的利尿作用，生化和血液学状态变化极小。唯一的不良反应是1例患者的胃部不适。
Bumetanide, a pharmacologically new diuretic, was evaluated in 27 subjects. Its onset of action was within 30 minutes with a peak at 90 minutes and a total duration of action of about 270 minutes. In a controlled study in oedematous patients it was equipotent with frusemide at one-fortieth the molar dosage and did not differ from frusemide with regard to its pattern of electrolyte excretion. On continuous oral administration for eight days it produced effective diuresis with minimal alteration in biochemical and haematological status. The only adverse effect was gastric discomfort in one patient.