Distribution of [14C]sulfur mustard in rats after intravenous exposure.
Distribution of [14C]sulfur mustard in rats after intravenous exposure.
复制标题
DOI：
10.1006/taap.1994.1074
复制
发表时间：
1994-04
影响因子：
3.8
通讯作者：
A. Maisonneuve;I. Callebat;L. Debordes;L. Coppet
中科院分区：
文献类型：
--
作者：
A. Maisonneuve;I. Callebat;L. Debordes;L. Coppet
研究了硫芥二(2-氯乙基)硫化物在大鼠体内的分布。静脉注射后。注射[14C]硫芥末(10 mg/kg)后，14C在所有被采样组织中的分布迅速(在几分钟内)。在肾、肝、肺、肠和胃中检测到大量的14C，这些器官都与消除和转化过程有关。在脂肪组织中回收的14C不超过3+/-2%，表明脂肪不是硫磺芥菜的主要储存部位。除了广泛的分布外，通过股浅静脉注射[14C]硫芥(10毫克/公斤或500微克/公斤)的小腿的腱膜中也观察到显著的14C摄取。经颈静脉注射[14C]硫芥末后，肺内未检测到14C的优势滞留部位。
The distribution of sulfur mustard, bis(2-chloroethyl)sulfide, was investigated in rats. After i.v. injection of [14C]sulfur mustard (10 mg/kg), distribution of 14C was rapid (within minutes) to all tissues that were sampled. Significant amounts of 14C were detected in the kidney, liver, lung, intestine, and stomach, organs all associated with elimination and transformation processes. No more than 3 +/- 2% of the 14C was recovered in fat tissues, indicating that fat was not a major storage site for sulfur mustard. In addition to wide distribution, a significant uptake of 14C was observed in an aponeurosis in the leg receiving the dose of [14C]sulfur mustard (10 mg/kg or 500 micrograms/kg) via the superficial femoral vein. After injection of [14C]sulfur mustard via the jugular vein, no preferential retention site for 14C was detected in the lung.