Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification.
Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification.
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DOI：
10.3389/fcvm.2022.918056
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发表时间：
2022
影响因子：
3.6
通讯作者：
Li, Fei
中科院分区：
文献类型：
--
作者：
Rao, Zhenqi;Zheng, Yidan;Xu, Li;Wang, Zihao;Zhou, Ying;Chen, Ming;Dong, Nianguo;Cai, Zhejun;Li, Fei
关键词：
血管钙化(Vc)是以血管壁磷酸钙沉积为特征的疾病，与许多疾病相关，并增加心血管疾病的发病率和死亡率。然而，VC发生发展和发病机制的分子机制尚不完全清楚，从而阻碍了VC分子靶向治疗的设计。近年来，一些研究表明内质网应激可加重VC。内质网是细胞内的膜性细胞器，参与分泌和跨膜蛋白的合成、折叠、成熟和翻译后修饰。内质网应激(ERS)发生在内质网环境中，当未折叠/错误折叠的蛋白质在内质网环境中干扰后积累时发生。因此，下调病理性ERS可能会减弱VC。本文就ERS与VC的关系作一综述，重点介绍ERS如何通过促进成骨转化、炎症、自噬和细胞凋亡来调控VC的发育，尤其是发生在各种血管细胞中的分子机制。我们还讨论了ERS抑制对VC相关疾病进展的治疗作用。
Vascular calcification (VC) is characterized by calcium phosphate deposition in blood vessel walls and is associated with many diseases, as well as increased cardiovascular morbidity and mortality. However, the molecular mechanisms underlying of VC development and pathogenesis are not fully understood, thus impeding the design of molecular-targeted therapy for VC. Recently, several studies have shown that endoplasmic reticulum (ER) stress can exacerbate VC. The ER is an intracellular membranous organelle involved in the synthesis, folding, maturation, and post-translational modification of secretory and transmembrane proteins. ER stress (ERS) occurs when unfolded/misfolded proteins accumulate after a disturbance in the ER environment. Therefore, downregulation of pathological ERS may attenuate VC. This review summarizes the relationship between ERS and VC, focusing on how ERS regulates the development of VC by promoting osteogenic transformation, inflammation, autophagy, and apoptosis, with particular interest in the molecular mechanisms occurring in various vascular cells. We also discuss, the therapeutic effects of ERS inhibition on the progress of diseases associated with VC are detailed.
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影响因子：
10.8
作者：
Durham AL;Speer MY;Scatena M;Giachelli CM;Shanahan CM
通讯作者：
Shanahan CM
影响因子：
7.2
作者：
Braakman, Ineke;Hebert, Daniel N.
通讯作者：
Hebert, Daniel N.
影响因子：
2.7
作者：
Cheng, Zhi-Yuan;Ye, Ting;Zong, Gang-Jun
通讯作者：
Zong, Gang-Jun
影响因子：
7.3
作者：
Chernomordik F;Cercek B;Lio WM;Mihailovic PM;Yano J;Herscovici R;Zhao X;Zhou J;Chyu KY;Shah PK;Dimayuga PC
通讯作者：
Dimayuga PC
DOI：
10.1161/atvbaha.113.300647
发表时间：
2013-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Cheng SL;Shao JS;Behrmann A;Krchma K;Towler DA
通讯作者：
Towler DA