Amide proton transfer imaging for the determination of human papillomavirus status in patients with oropharyngeal squamous cell carcinoma
Amide proton transfer imaging for the determination of human papillomavirus status in patients with oropharyngeal squamous cell carcinoma
复制标题
酰胺质子转移成像测定口咽鳞状细胞癌患者人乳头瘤病毒状态
DOI：
10.1097/md.0000000000029457
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kudo K.
中科院分区：
文献类型：
--
作者：
Fujima N*;Shimizu Y;Yoneyama M;Nakagawa J;Kameda H;Harada T;Hamada S;Suzuki T;Tsushima N;Kano S;Homma A;Kudo K.
本研究的目的是探讨酰胺质子转移（APT）成像在口咽鳞状细胞癌（SCC）患者中测定人乳头瘤病毒（HPV）状态的效用。对31例口咽鳞状细胞癌患者进行回顾性评价。所有患者均采用3T磁共振（MR）装置进行酰胺质子转移成像。根据原发肿瘤的病理表现，将患者分为hpv阳性组和阴性组。在APT成像中，原发肿瘤以多边形感兴趣区域（ROI）划定。利用ROI中的信号信息计算APT信号的均值、标准差（SD）和变异系数（CV）（分别为APT mean、APT SD和APT CV）。hpv阳性组APT CV值（0.43±0.04）显著低于hpv阴性组（0.48±0.04）(P=。01)。两组间APT均值差异无统计学意义(P=。82)或APT SD (P=。13) hpv阳性和阴性组之间的差异。APT CV的受试者工作特征（ROC）曲线分析灵敏度为0.75，特异性为0.8，阳性预测值为0.75，阴性预测值为0.8，准确度为0.77，曲线下面积（AUC）为0.8。与hpv阳性组相比，hpv阴性组的APT信号被认为是异质性的。这一信息可能有助于确定口咽鳞状细胞癌患者的HPV状态。
The aim of this study was to investigate the utility of amide proton transfer (APT) imaging for the determination of human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (SCC). Thirty-one patients with oropharyngeal SCC were retrospectively evaluated. All patients underwent amide proton transfer imaging using a 3T magnetic resonance (MR) unit. Patients were divided into HPV-positive and-negative groups depending on the pathological findings in their primary tumor. In APT imaging, the primary tumor was delineated with a polygonal region of interest (ROI). Signal information in the ROI was used to calculate the mean, standard deviation (SD) and coefficient of variant (CV) of the APT signals (APT mean, APT SD, and APT CV, respectively). The value of APT CV in the HPV-positive group (0.43±0.04) was significantly lower than that in the HPV-negative group (0.48±0.04)(P=. 01). There was no significant difference in APT mean (P=. 82) or APT SD (P=. 13) between the HPV-positive and-negative groups. Receiver operating characteristic (ROC) curve analysis of APT CV had a sensitivity of 0.75, specificity of 0.8, positive predictive value of 0.75, negative predictive value of 0.8, accuracy of 0.77 and area under the curve (AUC) of 0.8. The APT signal in the HPV-negative group was considered heterogeneous compared to the HPV-positive group. This information might be useful for the determination of HPV status in patients with oropharyngeal SCC.