Reply: Heterogeneous neuroimaging findings, damage propagation and connectivity: an integrative view.
Reply: Heterogeneous neuroimaging findings, damage propagation and connectivity: an integrative view.
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答复：异质神经影像学发现、损伤传播和连接：综合观点。
DOI：
10.1093/brain/awz081
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Fox,MichaelD
中科院分区：
文献类型：
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作者：
Darby,RRyan;Fox,MichaelD
先生，我们感谢Cauda等人(2019)的来信，他们讨论了我们最近的论文的含义，其中我们表明，看似不同的神经成像结果可以复制到普通的大脑网络(Darby等人，2018a)。作者提出了一个普遍的“路径连通性模型”来理解大脑疾病。他们提出了他们模型的三个含义，我们在下面做出回应。我们同意Cauda等人(2019)的观点，即网络定位与症状匹配，而不是潜在的病理。我们调查了具有相同临床痴呆综合征，但不一定具有相同潜在神经病理诊断的患者的神经成像研究。例如，行为变异型额颞叶痴呆的患者可能有tau或TDP-43病理，皮质-基底综合征患者可能有tau或阿尔茨海默氏病的病理，但这些不同的病理导致相似的临床症状并局限于相同的大脑网络。第二，我们发现了脑损伤和阿尔茨海默病患者妄想的共同网络定位(Darby等人，2018a)，以及脑损伤和精神疾病(如紧张症、非癫痫)患者的自由意志障碍知觉障碍
Sir, We thank Cauda et al.(2019) for their letter discussing the implications of our recent paper in which we showed that seemingly heterogeneous neuroimaging findings are reproducible to common brain networks (Darby et al., 2018a). The authors propose a generalized ‘pathoconnectivity model’for understanding brain diseases. They suggest three implications of their model, which we respond to below.We agree with Cauda et al.(2019) that network localization matches symptoms, not underlying pathology. We investigated neuroimaging studies of patients with the same clinical dementia syndromes, but not necessarily the same underlying neuropathological diagnosis. For instance, patients with behavioral variant frontotemporal dementia can have either tau or TDP-43 pathology, and patients with corticobasal syndrome can have either tau or Alzheimer’s pathology, yet these different pathologies result in similar clinical symptoms and localize to the same brain network. Second, we found common network localization for delusions in patients with brain lesions and Alzheimer’s disease (Darby et al., 2018a), and for disordered free will perception in patients with brain lesions and psychiatric diseases like catatonia, non-epileptic