Prognostic factors in breast cancer: the predictive value of the Nottingham Prognostic Index in patients with a long-term follow-up that were treated in a single institution
Prognostic factors in breast cancer: the predictive value of the Nottingham Prognostic Index in patients with a long-term follow-up that were treated in a single institution
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DOI：
10.1016/s0959-8049(00)00435-4
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发表时间：
2001-03-01
影响因子：
8.4
通讯作者：
Ferrarese, F
中科院分区：
文献类型：
--
作者：
D'Eredita, G;Giardina, C;Ferrarese, F
诺丁汉预后指数(NPI)是ATL指数，来源于一项回溯性多变量研究，能够预测乳腺癌患者的生存。该指数基于肿瘤大小、淋巴结分期和组织学分级，并允许将患者分为三个不同的预后组。这项研究的目的是根据我们长期随访的经验来验证。通过生存回归分析确定各预后变量对生存率的独立影响。然后，我们将NPI应用于同一组患者，以评估该指数的预测力和重复性。对1979年1月至1987年12月收治的402例患者进行了评估。多变量：分析(COX比例风险模型)。只有肿瘤大小、淋巴结转移和组织学分级仍是独立的预后因素。应用NPI后得到的生存曲线与我们的多变量分析得出的具有独立预后意义的因素的生存曲线相似。我们存活率的提高可能归功于对更多患者进行辅助治疗。NPI使我们能够准确地预测预后，我们主张更普遍地使用它。(C)2001爱思唯尔科学有限公司。保留所有权利。
The Nottingham Prognostic index (NPI) is atl index, derived from a retrospective multivariate study, that is able to predict survival in patients with breast cancer. The index is based on tumour size, lymph node stage and histological grade and allows the stratification of patients into three different prognostic groups. The aim of this study was to verify, according to our experience with a long-term follow-up. the effect of some prognostic variables on survival and to establish the independent influence of each of them by means of a survival regression analysis. Then we applied the NPI to the same group of patients in order to assess the predictive power and reproducibility of the index. 402 patients treated from January 1979 to December 1987 were evaluated. In multivariate: analysis (Cox proportional hazard model). only size, lymph node involvement and histological grade remained independent prognostic factors. The survival curves obtained after applying the NPI are similar to those for the factors with independent prognostic significance derived from our multivariate analysis. Our improved survival rates may be attributed to the administration of adjuvant therapies to a larger number of patients. The NPI allow us to accurately predict prognosis and we advocate its more common use. (C) 2001 Elsevier Science Ltd. All rights reserved.