Symptom improvement in co-occurring PTSD and alcohol dependence
Symptom improvement in co-occurring PTSD and alcohol dependence
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DOI：
10.1097/01.nmd.0000235794.12794.8a
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发表时间：
2006-09-01
影响因子：
1.9
通讯作者：
Verduin, Marcia L.
中科院分区：
文献类型：
--
作者：
Back, Sudie E.;Brady, Kathleen T.;Verduin, Marcia L.
本研究调查了参加一项为期12周的门诊治疗研究的个体在PTSD和酒精依赖症状改善的时间过程。参与者是94名同时患有创伤后应激障碍和酒精依赖的人，他们参加了一项双盲、安慰剂对照的药物试验。结果测量包括PTSD症状（用临床医生管理的PTSD量表、事件影响量表和平民密西西比PTSD量表测量）和酒精使用严重程度（用时间线追踪法测量）。两种疾病均有改善的个体的研究完成率明显更高。创伤后应激障碍的改善对酒精依赖症状的改善的影响大于相互关系。特别是，过度觉醒PTSD症状的改善与酒精使用的显著改善有关。对症状改善的时间过程的检查显示，酒精症状倾向于在PTSD症状之前或与PTSD症状一起开始改善。虽然是初步的，但这些发现表明，同时发生的PTSD症状可能对酒精依赖的治疗结果有很大的影响，PTSD治疗可能对优化合并PTSD和酒精依赖患者的治疗结果很重要。
This study investigated the temporal course of improvement in PTSD and alcohol dependence symptoms among individuals participating in a 12-week outpatient treatment study. Participants were 94 individuals with comorbid PTSD and alcohol dependence enrolled in a double-blind, placebo-controlled medication trial. Outcome measures included PTSD symptoms (as measured by the Clinician Administered PTSD Scale, Impact of Events Scale, and Civilian Mississippi Scale for PTSD) and alcohol use severity (as measured by the Time Line Follow Back). Study completion rates were significantly higher for individuals who demonstrated improvement in both disorders. Improvements in PTSD had a greater impact on improvement in alcohol dependence symptoms than the reciprocal relationship. Improvement in hyperarousal PTSD symptoms, in particular, was related to substantially improved alcohol use. Examination of the temporal course of symptom improvement revealed that alcohol symptoms tended to start improving either before or in conjunction with PTSD symptoms. Although preliminary in nature, these findings suggest that cooccurring PTSD symptoms may have a strong impact on alcohol dependence treatment outcome, and that PTSD treatment may be important to optimizing outcomes for patients with comorbid PTSD and alcohol dependence.