The role of sex hormones in the kinetics of chondrocytes in the growth plate - A study in the rabbit
The role of sex hormones in the kinetics of chondrocytes in the growth plate - A study in the rabbit
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DOI：
10.1302/0301-620x.87b9.15583
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Kokubun, S
中科院分区：
文献类型：
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作者：
Irie, T;Aizawa, T;Kokubun, S
性激素在骺生长板软骨细胞增殖、成熟和死亡的调控中起重要作用。我们研究了雄性去势对软骨细胞增殖和死亡细胞数量的影响。取正常兔和8周龄去势兔10、15、20、25周龄生长板，研究表明去势导致生长板软骨细胞凋亡增加，增殖减少。此外，去势兔软骨细胞数量少于同龄正常动物。
Sex hormones play important roles in the regulation of the proliferation, maturation and death of chondrocytes in the epiphyseal growth plate. We have investigated the effects of male castration on the cell kinetics of chondrocytes as defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and animals castrated at eight weeks of age were obtained at 10, 15, 20 and 25 weeks of age.Our study suggested that castration led to an increase in apoptosis and a decrease in the proliferation of chondrocytes in the growth plate. In addition, the number of chondrocytes in the castrated rabbits was less than that of normal animals of the same age.