Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.
Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.
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DOI：
10.1016/j.immuni.2016.09.015
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发表时间：
2016-10-18
期刊：
影响因子：
32.4
通讯作者：
Walker, Bruce D.
中科院分区：
文献类型：
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作者：
Ranasinghe, Srinika;Lamothe, Pedro A.;Soghoian, Damien Z.;Kazer, Samuel W.;Cole, Michael B.;Shalek, Alex K.;Yosef, Nir;Jones, R. Brad;Donaghey, Faith;Nwonu, Chioma;Jani, Priya;Clayton, Gina M.;Crawford, Frances;White, Janice;Montoya, Alana;Power, Karen;Allen, Todd M.;Streeck, Hendrik;Kaufmann, Daniel E.;Picker, Louis J.;Kappler, John W.;Walker, Bruce D.
CD8+ T细胞对病毒感染细胞的识别通常受到主要组织相容性复合体（MHC） I类的限制，尽管在cd4缺陷小鼠和使用重组巨细胞病毒载体的猕猴SIV疫苗试验中报道了MHC II类限制的罕见例子。在这里，我们证明了在一小部分hiv感染者中存在人类白细胞抗原（HLA） ii类限制性CD8+ T细胞反应，具有抗病毒特性。在这些个体中，T细胞受体β (TCRβ)分析显示ii类限制性CD8+ T细胞进行克隆扩增并介导hiv感染细胞的杀伤。在一个案例中，这些细胞占循环CD8+ T细胞的12%，TCRα分析显示有两种不同的共表达TCRα链，其中只有一条与II类hla肽复合物结合。这些数据表明，ii类限制性CD8+ T细胞反应可能存在于慢性人类病毒感染中，并可能有助于免疫控制。受HLA-DRB1限制的CD8+ T细胞存在于少数hiv感染者中，这些CD8+ T细胞对hiv感染细胞具有强大的抗病毒功能。TCRβ的使用模式表明ii类限制性CD8+ T细胞的克隆扩增违反免疫范式的CD8+ T细胞可能有助于病毒控制，MHC ii类限制性CD8+ T细胞已在cd4缺陷小鼠和SIV疫苗试验中报道。Ranasinghe等人证明，HLA ii类限制性CD8+ T细胞也存在于一小部分hiv感染个体中，对hiv感染细胞表现出强大的抗病毒功能，并表现出非典型的TCR使用模式。
CD8+ T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8+ T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8+ T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8+ T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8+ T cell responses can exist in a chronic human viral infection, and may contribute to immune control. CD8+ T cells restricted by HLA-DRB1 exist in a small number of HIV-infected persons These CD8+ T cells exhibit potent antiviral functions against HIV-infected cells TCRβ usage patterns indicate clonal expansion of class II-restricted CD8+ T cells CD8+ T cells that violate immunologic paradigms may contribute to viral control MHC class II-restricted CD8+ T cells have been reported in Cd4-deficient mice and an SIV vaccine trial. Ranasinghe et al. demonstrate that HLA class II-restricted CD8+ T cells also exist in a small percentage of HIV-infected individuals, show potent antiviral functions against HIV-infected cells, and exhibit atypical TCR usage patterns.
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DOI：
10.1126/science.aac9475
发表时间：
2016-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Picker LJ
影响因子：
4.4
作者：
Horton, Helen;Frank, Ian;McElrath, M. Juliana
通讯作者：
McElrath, M. Juliana
DOI：
10.1084/jem.20070784
发表时间：
2007-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Almeida JR;Price DA;Papagno L;Arkoub ZA;Sauce D;Bornstein E;Asher TE;Samri A;Schnuriger A;Theodorou I;Costagliola D;Rouzioux C;Agut H;Marcelin AG;Douek D;Autran B;Appay V
通讯作者：
Appay V
影响因子：
30.5
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影响因子：
10.5
作者：
Carrington M;Walker BD
通讯作者：
Walker BD